Investigators acknowledge the limitations of rodent or non-human primate stroke models,
hundreds of putative neuroprotectants have been evaluated in preclinical models, but not …

Pericytes are branched cells located in the wall of capillary blood vessels that are found
throughout the body, embedded within the microvascular basement membrane and …

Human diseases may be modeled in animals to allow preclinical assessment of putative
new clinical interventions. Recent, highly publicized failures of large clinical trials called into …

Background Small extracellular vesicles (sEV) secreted by mesenchymal stem cells (MSC)
derived from human induced pluripotent stem cells (iPSC, iMSC-sEV) are considered to …

We search for ischemic stroke treatment knowing we have failed—intensely and often—to
translate mechanistic knowledge into treatments that alleviate our patients' functional …

Pericytes are functional components of the neurovascular unit (NVU). They provide support
to other NVU components and maintain normal physiological functions of the blood-brain …

Stroke is a major cause of death and long-term disability accompanied by steep social and
medical costs. Diabetes mellitus (DM) is a chronic, lifelong, severe metabolic health problem …

Stroke remains the number one cause of morbidity in the United States. Within weeks to
months after an ischemic event, there is a resolution of inflammation and evidence of …

Ischemic stroke remains one of most common causes of death and disability worldwide.
Stroke triggers a cascade of events leading to rapid neuronal damage and death …

Acute ischemic stroke is inadequately treated in the USA and worldwide due to a lengthy
history of neuroprotective drug failures in clinical trials. The majority of victims must endure …