While several large pivotal clinical trials recently revealed a substantial benefit of
endovascular thrombectomy for acute ischemic stroke (AIS) caused by large-vessel …

Stroke therapy has entered a new era highlighted by the use of endovascular therapy in
addition to intravenous thrombolysis. However, the efficacy of current therapeutic regimens …

Identification of intracranial, atherosclerosis-related, large vessel occlusion (ICAS-LVO) is
important to set up an optimal endovascular treatment strategy, as most ICAS-LVOs require …

During the initial stages of hemorrhagic stroke, including intracerebral hemorrhage and
subarachnoid hemorrhage, the reflex mechanisms are activated to protect cerebral …

Introduction The neuroprotective benefit of therapeutic hypothermia (TH) has been
demonstrated, but systemic side effects and time required to achieve effective TH in acute …

Acute ischemic stroke is devastating to patients and their families because of few viable
therapeutic options to promote recovery after reperfusion windows close. Recent …

The advantage of animal studies is to study a relatively homogeneous group of animals
instead of a heterogeneous group of patients in clinical studies. Animal studies also offer a …

Ischemia-reperfusion injury (IRI) is an important cause of adverse prognosis after
recanalization in patients with acute occlusion of major intracranial artery (AOMIA). Here, we …

Reperfusion injury (RI) is a harmful complication that takes place during recanalization
treatment of ischemic organs. Currently, there are no efficacious treatments for protecting the …

Ischemic stroke and cerebral infarction triggered by the blockage of blood supply can cause
damage to the brain via a complex series of pathological changes. Recently, diverse …