Significance: Blood–brain barrier (BBB) disruption is a major pathological change after
intracerebral hemorrhage (ICH) and is both the cause and result of oxidative stress and of …

Vascular permeability is a selective mechanism that maintains the exchange between
vessels, tissues, and organs. The regulation was mostly studied during the nineteenth …

Diabetic retinopathy (DR) is the leading cause of blindness in working-age adults. Vascular
pericyte degeneration is the predominant clinical manifestation of DR, yet the mechanism …

Diabetes mellitus (DM) has become a vital societal problem as epidemiological studies
demonstrate the increasing incidence of type 1 and type 2 diabetes. Lesions observed in the …

Vascular basement membrane (BM) thickening has been hailed over half a century as the
most prominent histological lesion in diabetic microangiopathy, and represents an early …

Extracellular matrix (ECM)-mimicking biomaterials are considered effective tissue-
engineered scaffolds for regenerative medicine because of their biocompatibility …

Diabetes-associated complications, such as retinopathy, nephropathy, cardiomyopathy, and
atherosclerosis, the main consequences of long-term hyperglycemia, often lead to organ …

Diabetic retinopathy (DR) is an expanding global health problem, the exact mechanism of
which has not yet been clarified clearly, new insights into retinal physiology indicate that …

The microcirculation plays a key role in delivering oxygen to and removing metabolic wastes
from energy-intensive retinal neurons. Microvascular changes are a hallmark feature of …

Ischemic stroke (IS) is a cerebrovascular disease causing high rates of disability and fatality.
In recent years, the concept of the neurovascular unit (NVU) has been accepted by an …