Diabetes mellitus and associated chronic hyperglycemia enhance the risk of acute ischemic
stroke and lead to worsened clinical outcome and increased mortality. However, post-stroke …

Ischemic stroke is a highly complex and devastating neurological disease. The sudden loss
of blood flow to a brain region due to an ischemic insult leads to severe damage to that area …

Background: Ischemic stroke is a devastating disease that causes long-term disability.
However, its pathogenesis is unclear, and treatments for ischemic stroke are limited. Recent …

Ischemic stroke is a leading cause of mortality and disability. Diabetes mellitus,
characterized by hyperglycemia, is a common concomitant disease of ischemic stroke …

Abstract P-glycoprotein (P-gp) is expressed on brain microvessel endothelial cells of blood-
brain barrier (BBB) and elevated after cerebral ischemia. In this study, we explored the …

The blood-brain barrier (BBB) is a fundamental component of the central nervous system
(CNS). Its functional and structural integrity is vital to maintain the homeostasis of the brain …

Postoperative cognitive dysfunction is extremely prevalent following cardiac surgery. The
increasing patient age and comorbidity profile increases their susceptibility to cognitive …

TRPM2 channel is activated by the increase of hypoxia (HYP)-mediated excessive
mitochondrial (mROS) and cytosolic (cROS) free reactive oxygen species generation and …

Ischemic stroke is a leading cause of morbidity and mortality among type 2 diabetic patients.
Preclinical and translational studies have identified critical pathophysiological mediators of …

Background Ischemic stroke is a main cause of mortality. Blood-brain barrier (BBB)
breakdown appears to play a critical role in inflammation in patients with ischemic stroke …