Spontaneous subarachnoid haemorrhage

J Claassen, S Park - The Lancet, 2022 - thelancet.com
Subarachnoid haemorrhage (SAH) is the third most common subtype of stroke. Incidence
has decreased over past decades, possibly in part related to lifestyle changes such as …

Advances in acute ischemic stroke therapy

Y Xiong, AK Wakhloo, M Fisher - Circulation research, 2022 - Am Heart Assoc
The treatment of acute ischemic stroke continues to advance. The mainstay of treatment
remains intravenous thrombolysis with alteplase. Recent studies demonstrated that later …

Remote ischemic conditioning for acute stroke: the RESIST randomized clinical trial

RA Blauenfeldt, N Hjort, JB Valentin, AM Homburg… - JAMA, 2023 - jamanetwork.com
Importance Despite some promising preclinical and clinical data, it remains uncertain
whether remote ischemic conditioning (RIC) with transient cycles of limb ischemia and …

Metabolic contribution and cerebral blood flow regulation by astrocytes in the neurovascular unit

S Takahashi - Cells, 2022 - mdpi.com
The neurovascular unit (NVU) is a conceptual framework that has been proposed to better
explain the relationships between the neural cells and blood vessels in the human brain …

Cerebroprotective Role of N6-Methyladenosine Demethylase FTO (Fat Mass and Obesity-Associated Protein) After Experimental Stroke

AK Chokkalla, S Jeong, SL Mehta, CK Davis… - Stroke, 2023 - Am Heart Assoc
Background: FTO (fat mass and obesity-associated protein) demethylates N 6-
methyladenosine (m6A), which is a critical epitranscriptomic regulator of neuronal function …

Pleiotropic microenvironment remodeling micelles for cerebral ischemia-reperfusion injury therapy by inhibiting neuronal ferroptosis and glial overactivation

C Li, Y Wu, Q Chen, Y Luo, P Liu, Z Zhou, Z Zhao… - ACS …, 2023 - ACS Publications
Reperfusion injury presents a significant obstacle to neuronal survival following successful
recanalization in ischemic stroke, which is characterized by intricate pathophysiological …

Ischemic stroke, glucocorticoids, and remote hippocampal damage: a translational outlook and implications for modeling

NV Gulyaeva, MV Onufriev, YV Moiseeva - Frontiers in neuroscience, 2021 - frontiersin.org
Progress in treating ischemic stroke (IS) and its delayed consequences has been
frustratingly slow due to the insufficient knowledge on the mechanism. One important factor …

[HTML][HTML] The vessel has been recanalized: now what?

J Ospel, N Rex, S Kandregula, M Goyal - Neurotherapeutics, 2023 - Elsevier
When treating acute ischemic stroke patients in our daily clinical practice, we strive to
achieve recanalization of the occluded blood vessel as fast as possible using …

A comparative study of Koizumi and Longa methods of intraluminal filament middle cerebral artery occlusion in rats: early corticosterone and inflammatory response in …

MV Onufriev, YV Moiseeva, MY Zhanina… - International Journal of …, 2021 - mdpi.com
Two classical surgical approaches for intraluminal filament middle cerebral artery occlusion
(MCAO), the Longa et al.(LM) and Koizumi et al. methods (KM), are used as alternatives in …

[HTML][HTML] Stem cell-derived extracellular vesicle therapy for acute brain insults and neurodegenerative diseases

OY Bang, JE Kim - BMB reports, 2022 - ncbi.nlm.nih.gov
Stem cell-based therapy is a promising approach for treating a variety of disorders, including
acute brain insults and neurodegenerative diseases. Stem cells such as mesenchymal stem …