The polypeptide chains that make up proteins have thousands of atoms and hence millions
of possible inter-atomic interactions. It might be supposed that the resulting complexity …

Topology is at the very heart of chemistry. This stems from the fact that chemical thought,
since its prescientific alchemic origins, focused on the mutual relations between different …

An elementary statistical mechanical model was used to calculate the folding rates for 22
proteins from their known three-dimensional structures. In this model, residues come into …

▪ Abstract This review describes how kinetic experiments using techniques with dramatically
improved time resolution have contributed to understanding mechanisms in protein folding …

We report single-molecule folding studies of a small, single-domain protein, chymotrypsin
inhibitor 2 (CI2). CI2 is an excellent model system for protein folding studies and has been …

Mesoscopic organization in soft, hard, and biological matter is examined in the context of our
present understanding of the principles responsible for emergent organized behavior …

Abstract Comparison of the folding mechanisms of proteins with similar structures but very
different sequences can provide fundamental insights into the determinants of protein …

▪ Abstract Considerable recent progress has been made in the field of ab initio protein
structure prediction, as witnessed by the third Critical Assessment of Structure Prediction …

Guided by recent experimental results suggesting that protein-folding rates and mechanisms
are determined largely by native-state topology, we develop a simple model for protein …

The fastest simple, single domain proteins fold a million times more rapidly than the slowest.
Ultimately this broad kinetic spectrum is determined by the amino acid sequences that …