During the past year, advances in our understanding of folding mechanisms have been
made through detailed experimental and theoretical studies of a number of proteins. The …

Incorporating recent dramatic advances, this textbook presents a fresh and timely
introduction to modern biophysical methods. An array of new, faster and higher-power …

Human insulin is a double-chain peptide that is synthesized in vivo as a single-chain human
proinsulin (HPI). We have investigated the disulfide-forming pathway of a single-chain …

A new method for simulating the folding process of a protein is reported. The method is
based on the essential dynamics sampling technique. In essential dynamics sampling, a …

The hypothesis that folding robustness is the primary determinant of the evolution rate of
proteins is explored using a coarse-grained off-lattice model. The simplicity of the model …

An increasing number of folding studies of two-state proteins shows that point mutations
sometimes change the kinetic m-values, leading to kinks and curves in the chevron plots …

Investigators have recently turned to studies of protein families to shed light on the
mechanism of protein folding. In small proteins for which detailed analysis has been …

Protein misfolding is now recognized as playing a crucial role in both normal and
pathogenic folding reactions. An interesting example of misfolding at the earliest state of a …

Referee: Ilya A. Vakser, Department of Cell and Molecular Pharmacology, Medical
Univerisity of South Carolina 173 Ashley Avenue, PO Box 250505, Charleston, SC 294425 …

We have studied folding mechanisms of three small globular proteins: crambin,
chymotrypsin inhibitor 2 (CI2), and the fyn Src Homology 3 domain (SH3) which are …