Characterisation of the transition states for protein folding: towards a new level of mechanistic detail in protein engineering analysis
M Oliveberg - Current Opinion in Structural Biology, 2001 - Elsevier
The field of protein folding now offers considerable excitement. Comparative studies of the
transition-state structures for a series of protein families with analogous structures have …
transition-state structures for a series of protein families with analogous structures have …
Mapping the architecture of the HIV-1 Tat circuit: A decision-making circuit that lacks bistability and exploits stochastic noise
BS Razooky, LS Weinberger - Methods, 2011 - Elsevier
Upon infection of a CD4+ T cell, HIV-1 appears to 'choose'between two alternate fates:
active replication or a long-lived dormant state termed proviral latency. A transcriptional …
active replication or a long-lived dormant state termed proviral latency. A transcriptional …
Similarities between the spectrin SH3 domain denatured state and its folding transition state
We have expanded our description of the energy landscape for folding of the SH3 domain of
chicken α-spectrin by a detailed structural characterization of its denatured state ensemble …
chicken α-spectrin by a detailed structural characterization of its denatured state ensemble …
The anatomy of protein β-sheet topology
C Zhang, SH Kim - Journal of molecular biology, 2000 - Elsevier
Here, we present a systematic analysis of the open-faced β-sheet topologies in a set of non-
redundant protein domain structures; in particular, we focus on the topological diversity of …
redundant protein domain structures; in particular, we focus on the topological diversity of …
Different secondary structure elements as scaffolds for protein folding transition states of two homologous four‐helix bundles
K Teilum, T Thormann, NR Caterer… - Proteins: Structure …, 2005 - Wiley Online Library
Abstract Comparison of the folding processes for homologue proteins can provide valuable
information about details in the interactions leading to the formation of the folding transition …
information about details in the interactions leading to the formation of the folding transition …
Evolutionary conservation in protein folding kinetics
KW Plaxco, S Larson, I Ruczinski, DS Riddle… - Journal of molecular …, 2000 - Elsevier
The sequence and structural conservation of folding transition states have been predicted
on theoretical grounds. Using homologous sequence alignments of proteins previously …
on theoretical grounds. Using homologous sequence alignments of proteins previously …
Folding of electrostatically charged beads-on-a-string as an experimental realization of a theoretical model in polymer science
The “beads-on-a-string” model for folding of polymers is a cornerstone of theoretical polymer
science. This communication describes a physical model of beads-on-a-string, based on the …
science. This communication describes a physical model of beads-on-a-string, based on the …
Sequential vs. parallel protein-folding mechanisms: experimental tests for complex folding reactions
LA Wallace, CR Matthews - Biophysical chemistry, 2002 - Elsevier
The recent emphasis on rough energy landscapes for protein folding reactions by
theoreticians, and the many observations of complex folding kinetics by experimentalists …
theoreticians, and the many observations of complex folding kinetics by experimentalists …
Structural determinants of the rate of protein folding
B Nölting, W Schälike, P Hampel, F Grundig… - Journal of theoretical …, 2003 - Elsevier
To understand the mechanism of protein folding and to assist rational design of fast-folding,
non-aggregating and stable artificial enzymes, it is essential to determine the structural …
non-aggregating and stable artificial enzymes, it is essential to determine the structural …
Guided macro-mutation in a graded energy based genetic algorithm for protein structure prediction
Protein structure prediction is considered as one of the most challenging and
computationally intractable combinatorial problem. Thus, the efficient modeling of …
computationally intractable combinatorial problem. Thus, the efficient modeling of …