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Oct 2014 31 
PHYSIOLOGY DUE TO YOGA 
INTRODUCTION 
There is an intimate relationship between 
aspects of yoga practice and human physiology. 
It is usual to contemplate the relation in terms 
of how one could explain health effects of yoga 
through some physiological measurements. 
Electrophysiologic and biochemical methods 
of investigations have been often used to 
determine the effects and health benefits of Yoga 
practices. The practices are usually focused on 
asanas, pranayama and sometimes, meditation 
and rarely dhyana. This paper looks into the 
new and emerging areas of physiology that result 
from a knowledge of Yoga. We turn around the 
telescope as it were, to reveal the microscopic 
inner world of prana and nadis to understand 
the contributions of Yoga to enhance our 
perspective of human physiology. In this issue, 
g Prof. T M Srinivasan 
Dean, Yoga and Physical Sciences, 
S-VYASA 
we present just four important aspects of Yoga 
which could expand our understanding of the 
human mind-body-Spirit triad. 
1. Lateralization of brain functions 
in Swara Yoga 
2. Role of muscle stretch in rehabilitation 
3. Blood flow in brain due to pranayama 
and treatment possibilities 
4. Theoretical postulates of quantum 
mechanics and consciousness 
This is not an exhaustive list by any means; 
however, this gives an overview of many 
research studies that could manifest in the years 
to come. Some esoteric aspects of Yoga practice 
will be taken up in the next issue of this journal. 
Let us look at each of the items listed in some 
details. 
1. Lateralization of brain functions 
in Swara Yoga 
Swara Yoga is the occurrence of alternate nostril 
dominance in breathing that all of us go through 
in a day. At any time, normally, either the left 
nostril or the right nostril is dominant; in other 
words, one nostril is blocked and the other is 
open and facilitates breathing. After some time, 
say between 90 minutes and 120 minutes, the 
dominance switches; the second nostril takes over 
and the nostril that was active will be blocked. 
This happens due to changes in blood flow in the 
nostril; the more the blood flow in one side of the 
body, the nostril on that side is blocked, since 
the erectile tissue on that side expand to block 
Fig 1: Pranayama and Healing Energy Exchange 
29
air flow through that nostril! Though the blood 
flow and biochemistry are slightly different in 
both sides of the body, presently it is thought 
to be clinically inconsequential. To summarize, 
a vasoconstriction in one nasal turbinate is 
paralleled by vasodilation in the other nostril. 
The nasal mucosa are densely innervated 
with autonomic fibers and the dominance of 
sympathetic activity on one side produces 
vasoconstriction in the turbinates, while the 
contralateral nostril exhibits a simultaneous 
dominance of parasympathetic activity that 
causes swelling [1]. “Shiva Swarodaya, a classical 
yogic text describes the ultradian nasal cycle 
as Swarodaya Vigyan and highlights differential 
effects of its phases that reflect the lunar cycles” 
[2]. 
Though some studies [1-3] investigate the 
dynamics of breathing at gross and subtle 
levels, its application in clinical medicine is very 
limited. Many unilateral problems could be 
related to improper functioning of nasal rhythm 
[4, 5]. Many psychiatric disorders, autism, 
stress related disorders etc could be studied for 
management through introduction of unilateral 
breathing. In a study, cases of glaucoma were 
found to have improper nasal rhythm [4]. In 
such cases, left hemisphere of the brain was 
activated through right nostril breathing which 
seems to decrease intra-ocular pressure. If 
this could be substantiated in well controlled 
experiments, it is a boon to our patients. Since 
India has the highest number of adult blind, this 
simple procedure could help immensely in rural 
areas. 
Another report looked at ADHD (Attention 
Deficit Hyper-activity Disorder) wherein forced 
nostril breathing through non-dominant nostril 
produced increased arousal in the individual 
reducing ADHD symptoms [5]. This case study 
should be studied extensively for proper clinical 
application. Thus, study of Swara Yoga and its 
physiology could open new doors of physiology 
and treatment methods. 
32 Yoga Sudha 
Fig 2: Ida and Pingala as depicted in Tibetan Medicine 
2. Role of muscle stretch 
in Rehabilitation 
Yoga asanas constitute dynamic and static 
postures wherein movement and maintenance of 
postures are vital. While muscles are exercised in 
weight bearing, the antagonists (opposing group 
of muscles) are stretched properly. Muscle stretch 
has come under intense scrutiny in many rehab 
clinics worldwide [6]. In the experience of this 
author, even complex neuromuscular problems 
such as Parkinson’s tremor could be managed and 
improved through proper selection and practice 
of asanas and pranayama. Stretch of a muscle 
has many important functions including control 
of muscle in movement; unilateral and bilateral 
stretches, speed of movement and maintaining 
the stretch could all provide wide variety of 
possibilities in most neuromuscular problems. 
Yoga asanas could provide a new perspective 
for understanding reflex mechanisms that are 
elicited during stretch and its role in control and 
coordination of muscles. 
Further, it is interesting to determine how 
movement of skeletal muscles and pranayama 
30
Oct 2014 33 
could facilitate expression of certain biochemicals 
in the brain. This seems to be the case in the 
above cited muscle tremor problem. In the well-cited 
case of GABA production in the brain due 
to Yoga practices as an antidote for depression, 
the role of Yoga in changing biochemistry 
of the brain is exciting. This fascinating area 
needs intense work to clarify – not the familiar 
psychoneuroimmunology – but muscle-respiration- 
brain biochemistry dynamics. 
‘Molecules of emotions’ is now a familiar territory; 
however, ‘molecules of motion’ is not! 
3. Blood flow in brain due 
to pranayama and treatment 
possibilities 
Pranayama is a powerful method for readjusting 
flow of prana throughout the body. Normal 
functioning of prana and its uniform distribution 
in the body are characterized by healthy 
performance of organs of the body. When one 
holds the breath (either after inhale or exhale), 
there is a slight increase in carbon dioxide in 
blood which has many complex responses in the 
body and brain. Some of the effects have come 
to light recently [7]. One aspect of importance is 
the resultant increase in lumen of blood vessels 
of the brain and subsequent increase in oxygen 
flow to the brain. Hence, to improve brain oxygen, 
a simple breath holding for 15 sec seems to be 
sufficient. One could imagine the result of such a 
simple procedure in rehabilitation of all types of 
CNS (Central Nervous System) problems: post-stroke 
rehab, kick starting mirror neurons in the 
brain in autism spectrum disorders, learning 
related problems, dyslexia, short term memory 
lapses in elderly and in numerous areas. Further, 
daily expansion and contraction of brain blood 
vessels could provide an antidote for plaque 
formation and its attachment in the brain blood 
vessels. This, if proved to be so, could be of 
immense help in prevention and management 
of many stroke-related problems. 
4. Theoretical postulates of quantum 
mechanics and consciousness 
At last to the Self! It is said that science in general 
separates; however, quantum mechanics seems 
to integrate diverse elements in a system. At 
least it interconnects and seems to provide a 
platform for theories regarding certain healing 
methods such as distance healing and prana/chi 
related techniques. Interconnectedness happens 
only if entities are separate and in so-called 
independent systems. It is similar to genetics 
and epigenetics; genetics gives a fixed form 
and epigenetics provides varied and individual 
pastoral colors to our behavior and activities. 
It has been argued that neither genetics nor 
epigenetics provide a complete picture of a 
human whose imprints in the subtle system 
could extend backwards for a million years [8]. 
We have independence to act now to transcend 
natural tendencies of recycling our body and 
mind (going through births in many realms) in a 
myriad ways. Unless we get into understanding 
our pregenetic make up, we are attached to this 
time and space-bound activities. Yoga has given 
a method for reaching Kaivalya, wherein one 
goes beyond gunas of satva, rajas and tamas. 
In some of our experiments and teachings, we 
have seen that gunas indeed progress towards 
qualities of satva - altruistic love and concern 
for all that exhibit life and even to those that 
seem to passively receive all our deeds and 
emotions. This is a universal model and Yoga 
practices could lead a person beyond the human 
perception of separation, self-styled anomalies 
and exclusiveness. 
We have not started searching the depths of 
concepts related to prana, chakras, energy 
pathways of ida and pingala and final ascent of 
the energy through susumna. See Fig 1 and 2 
for representations of energy exchange and its 
movement within the body. These are esoteric 
knowledge of ancients which could give us 
insight to the direction biological research 
could be taken for understanding some aspects 
of reality of nature and the nature of reality. In 
31
conclusion we may say that sciences separate, 
quantum mechanics interconnects while true 
spirituality integrates. Let us hope that Yogic 
horizon will light the skies of compassion, caring 
and consummate responsibility in the world of 
today. 
REFERENCES AND NOTES 
1. David S. Shannahoff-Khalsa, Psychophysiological 
States: The Ultradian Dynamics of Mind-Body 
Interactions, University of California, San Diego, USA, 
Elsevier, Amsterdam, 2008. Here is an outstanding 
book summarizing many years of work in the area 
of ultradian rhythm and nostril dominance. 
2. Ananda Balayogi Bhavanani et. al, “Immediate Effect 
of Alternate Nostril Breathing On Cardiovascular 
Parameters and Reaction Time”, International 
Interdisciplinary Research Journal, Vol. IV, Jan 2014, 
pp. 297-302. 
3. Raghuraj P, Telles S. “Immediate effect of specific 
nostril manipulating yoga breathing practices 
on autonomic and respiratory variables”. Appl. 
Psychophysiol. Biofeedback 33: 2008; pp. 65–75. 
4. Joshua Backon et. al, “Changes in intra-ocular 
pressure induced by differential forced unilateral 
nostril breathing”, Graefe’s Arch. Clin. Exp. 
Ophthalmology, 277: 1989, pp. 575-577. 
5. Narendran Thaiyar and T. M. Srinivasan, “Changes 
in arousal level through forced unilateral nostril 
breathing and a possible application”, Proc. 
International Society for the Study of Subtle Energies 
and Energy Medicine, Third Annual Conference, 
1992, pp. 67-69. 
6. Carolyn Kisner and Lynn Allen Colby, Therapeutic 
Exercises, Foundation and Techniques, F. A. Davis Co, 
USA, 5th Ed, 2007. 
7. McKay et.al, “A bilateral cortico-bulbar network 
associated with breath holding in humans, 
determined by fMRI”, Neuroimage, 40: 4, 2008, pp. 
1824-1832. 
8. T. M. Srinivasan, “Genetics, epigenetics and 
pregenetics”, International Journal of Yoga, 4: 2011; 
47-48. Genetics is the preprogramming of our genes 
through parental inputs; epigenetics is the role of 
nurture in changing genetic expressions. Pregenetics 
is the karmic imprints that we have acquired over 
millennia of our existence.

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PHYSIOLOGY DUE TO YOGA by Prof TM Srinivasan

  • 1. Oct 2014 31 PHYSIOLOGY DUE TO YOGA INTRODUCTION There is an intimate relationship between aspects of yoga practice and human physiology. It is usual to contemplate the relation in terms of how one could explain health effects of yoga through some physiological measurements. Electrophysiologic and biochemical methods of investigations have been often used to determine the effects and health benefits of Yoga practices. The practices are usually focused on asanas, pranayama and sometimes, meditation and rarely dhyana. This paper looks into the new and emerging areas of physiology that result from a knowledge of Yoga. We turn around the telescope as it were, to reveal the microscopic inner world of prana and nadis to understand the contributions of Yoga to enhance our perspective of human physiology. In this issue, g Prof. T M Srinivasan Dean, Yoga and Physical Sciences, S-VYASA we present just four important aspects of Yoga which could expand our understanding of the human mind-body-Spirit triad. 1. Lateralization of brain functions in Swara Yoga 2. Role of muscle stretch in rehabilitation 3. Blood flow in brain due to pranayama and treatment possibilities 4. Theoretical postulates of quantum mechanics and consciousness This is not an exhaustive list by any means; however, this gives an overview of many research studies that could manifest in the years to come. Some esoteric aspects of Yoga practice will be taken up in the next issue of this journal. Let us look at each of the items listed in some details. 1. Lateralization of brain functions in Swara Yoga Swara Yoga is the occurrence of alternate nostril dominance in breathing that all of us go through in a day. At any time, normally, either the left nostril or the right nostril is dominant; in other words, one nostril is blocked and the other is open and facilitates breathing. After some time, say between 90 minutes and 120 minutes, the dominance switches; the second nostril takes over and the nostril that was active will be blocked. This happens due to changes in blood flow in the nostril; the more the blood flow in one side of the body, the nostril on that side is blocked, since the erectile tissue on that side expand to block Fig 1: Pranayama and Healing Energy Exchange 29
  • 2. air flow through that nostril! Though the blood flow and biochemistry are slightly different in both sides of the body, presently it is thought to be clinically inconsequential. To summarize, a vasoconstriction in one nasal turbinate is paralleled by vasodilation in the other nostril. The nasal mucosa are densely innervated with autonomic fibers and the dominance of sympathetic activity on one side produces vasoconstriction in the turbinates, while the contralateral nostril exhibits a simultaneous dominance of parasympathetic activity that causes swelling [1]. “Shiva Swarodaya, a classical yogic text describes the ultradian nasal cycle as Swarodaya Vigyan and highlights differential effects of its phases that reflect the lunar cycles” [2]. Though some studies [1-3] investigate the dynamics of breathing at gross and subtle levels, its application in clinical medicine is very limited. Many unilateral problems could be related to improper functioning of nasal rhythm [4, 5]. Many psychiatric disorders, autism, stress related disorders etc could be studied for management through introduction of unilateral breathing. In a study, cases of glaucoma were found to have improper nasal rhythm [4]. In such cases, left hemisphere of the brain was activated through right nostril breathing which seems to decrease intra-ocular pressure. If this could be substantiated in well controlled experiments, it is a boon to our patients. Since India has the highest number of adult blind, this simple procedure could help immensely in rural areas. Another report looked at ADHD (Attention Deficit Hyper-activity Disorder) wherein forced nostril breathing through non-dominant nostril produced increased arousal in the individual reducing ADHD symptoms [5]. This case study should be studied extensively for proper clinical application. Thus, study of Swara Yoga and its physiology could open new doors of physiology and treatment methods. 32 Yoga Sudha Fig 2: Ida and Pingala as depicted in Tibetan Medicine 2. Role of muscle stretch in Rehabilitation Yoga asanas constitute dynamic and static postures wherein movement and maintenance of postures are vital. While muscles are exercised in weight bearing, the antagonists (opposing group of muscles) are stretched properly. Muscle stretch has come under intense scrutiny in many rehab clinics worldwide [6]. In the experience of this author, even complex neuromuscular problems such as Parkinson’s tremor could be managed and improved through proper selection and practice of asanas and pranayama. Stretch of a muscle has many important functions including control of muscle in movement; unilateral and bilateral stretches, speed of movement and maintaining the stretch could all provide wide variety of possibilities in most neuromuscular problems. Yoga asanas could provide a new perspective for understanding reflex mechanisms that are elicited during stretch and its role in control and coordination of muscles. Further, it is interesting to determine how movement of skeletal muscles and pranayama 30
  • 3. Oct 2014 33 could facilitate expression of certain biochemicals in the brain. This seems to be the case in the above cited muscle tremor problem. In the well-cited case of GABA production in the brain due to Yoga practices as an antidote for depression, the role of Yoga in changing biochemistry of the brain is exciting. This fascinating area needs intense work to clarify – not the familiar psychoneuroimmunology – but muscle-respiration- brain biochemistry dynamics. ‘Molecules of emotions’ is now a familiar territory; however, ‘molecules of motion’ is not! 3. Blood flow in brain due to pranayama and treatment possibilities Pranayama is a powerful method for readjusting flow of prana throughout the body. Normal functioning of prana and its uniform distribution in the body are characterized by healthy performance of organs of the body. When one holds the breath (either after inhale or exhale), there is a slight increase in carbon dioxide in blood which has many complex responses in the body and brain. Some of the effects have come to light recently [7]. One aspect of importance is the resultant increase in lumen of blood vessels of the brain and subsequent increase in oxygen flow to the brain. Hence, to improve brain oxygen, a simple breath holding for 15 sec seems to be sufficient. One could imagine the result of such a simple procedure in rehabilitation of all types of CNS (Central Nervous System) problems: post-stroke rehab, kick starting mirror neurons in the brain in autism spectrum disorders, learning related problems, dyslexia, short term memory lapses in elderly and in numerous areas. Further, daily expansion and contraction of brain blood vessels could provide an antidote for plaque formation and its attachment in the brain blood vessels. This, if proved to be so, could be of immense help in prevention and management of many stroke-related problems. 4. Theoretical postulates of quantum mechanics and consciousness At last to the Self! It is said that science in general separates; however, quantum mechanics seems to integrate diverse elements in a system. At least it interconnects and seems to provide a platform for theories regarding certain healing methods such as distance healing and prana/chi related techniques. Interconnectedness happens only if entities are separate and in so-called independent systems. It is similar to genetics and epigenetics; genetics gives a fixed form and epigenetics provides varied and individual pastoral colors to our behavior and activities. It has been argued that neither genetics nor epigenetics provide a complete picture of a human whose imprints in the subtle system could extend backwards for a million years [8]. We have independence to act now to transcend natural tendencies of recycling our body and mind (going through births in many realms) in a myriad ways. Unless we get into understanding our pregenetic make up, we are attached to this time and space-bound activities. Yoga has given a method for reaching Kaivalya, wherein one goes beyond gunas of satva, rajas and tamas. In some of our experiments and teachings, we have seen that gunas indeed progress towards qualities of satva - altruistic love and concern for all that exhibit life and even to those that seem to passively receive all our deeds and emotions. This is a universal model and Yoga practices could lead a person beyond the human perception of separation, self-styled anomalies and exclusiveness. We have not started searching the depths of concepts related to prana, chakras, energy pathways of ida and pingala and final ascent of the energy through susumna. See Fig 1 and 2 for representations of energy exchange and its movement within the body. These are esoteric knowledge of ancients which could give us insight to the direction biological research could be taken for understanding some aspects of reality of nature and the nature of reality. In 31
  • 4. conclusion we may say that sciences separate, quantum mechanics interconnects while true spirituality integrates. Let us hope that Yogic horizon will light the skies of compassion, caring and consummate responsibility in the world of today. REFERENCES AND NOTES 1. David S. Shannahoff-Khalsa, Psychophysiological States: The Ultradian Dynamics of Mind-Body Interactions, University of California, San Diego, USA, Elsevier, Amsterdam, 2008. Here is an outstanding book summarizing many years of work in the area of ultradian rhythm and nostril dominance. 2. Ananda Balayogi Bhavanani et. al, “Immediate Effect of Alternate Nostril Breathing On Cardiovascular Parameters and Reaction Time”, International Interdisciplinary Research Journal, Vol. IV, Jan 2014, pp. 297-302. 3. Raghuraj P, Telles S. “Immediate effect of specific nostril manipulating yoga breathing practices on autonomic and respiratory variables”. Appl. Psychophysiol. Biofeedback 33: 2008; pp. 65–75. 4. Joshua Backon et. al, “Changes in intra-ocular pressure induced by differential forced unilateral nostril breathing”, Graefe’s Arch. Clin. Exp. Ophthalmology, 277: 1989, pp. 575-577. 5. Narendran Thaiyar and T. M. Srinivasan, “Changes in arousal level through forced unilateral nostril breathing and a possible application”, Proc. International Society for the Study of Subtle Energies and Energy Medicine, Third Annual Conference, 1992, pp. 67-69. 6. Carolyn Kisner and Lynn Allen Colby, Therapeutic Exercises, Foundation and Techniques, F. A. Davis Co, USA, 5th Ed, 2007. 7. McKay et.al, “A bilateral cortico-bulbar network associated with breath holding in humans, determined by fMRI”, Neuroimage, 40: 4, 2008, pp. 1824-1832. 8. T. M. Srinivasan, “Genetics, epigenetics and pregenetics”, International Journal of Yoga, 4: 2011; 47-48. Genetics is the preprogramming of our genes through parental inputs; epigenetics is the role of nurture in changing genetic expressions. Pregenetics is the karmic imprints that we have acquired over millennia of our existence.