This Commentary clarifies the meaning of the funnel diagram, which has been widely cited
in papers on protein folding. To aid in the analysis of the funnel diagram, this Commentary …

Publisher Summary This chapter presents an overview of the theoretical aspects of the “new
view” of protein folding based on the energy landscape theory and the funnel concept. The …

We describe here a general model of the kinetic mechanism of protein folding. In the Foldon
Funnel Model, proteins fold in units of secondary structures, which form sequentially along …

Protein folding should be complex. Proteins organize themselves into specific three-
dimensional structures, through a myriad of conformational changes. The classical view of …

A lattice model of protein folding is developed to distinguish between amino acid sequences
that do and do not fold into unique conformations. Although Monte Carlo simulations provide …

During the past year, advances in our understanding of folding mechanisms have been
made through detailed experimental and theoretical studies of a number of proteins. The …

news and views Page 1 TG) 1995 Nature Publishing Group http://www.nature.com/nsmb
news and views Oxford Centre for Molecular Sciences, New Chemistry Laboratory …

Two fundamentally different views of how proteins fold are now being debated. Do proteins
fold through multiple unpredictable routes directed only by the energetically downhill nature …

Experimental and theoretical studies together are providing insights into the mechanism by
which proteins fold. Our present knowledge of the essential aspects of the folding reaction is …

The genome project, with the discovery of thousands of new protein sequences every year,
has created a revolution in protein physics, chemistry, and biology. This has led to a …