General mechanism of two-state protein folding kinetics
GC Rollins, KA Dill - Journal of the American Chemical Society, 2014 - ACS Publications
We describe here a general model of the kinetic mechanism of protein folding. In the Foldon
Funnel Model, proteins fold in units of secondary structures, which form sequentially along …
Funnel Model, proteins fold in units of secondary structures, which form sequentially along …
A speed limit for protein folding.
JA McCammon - Proceedings of the National Academy of …, 1996 - National Acad Sciences
Recent observations of fast steps in protein folding (1-3) address the following question:
what is the shortest time that would be required for folding? The paper by Hagen et al.(4) in …
what is the shortest time that would be required for folding? The paper by Hagen et al.(4) in …
Theory, simulations, and experiments show that proteins fold by multiple pathways
WA Eaton, PG Wolynes - Proceedings of the National …, 2017 - National Acad Sciences
In PNAS (1), Englander and Mayne repeat an assertion, already made by them along with
Bai and Sosnick in 1995 (2), that the modern energy landscape theory of protein folding, by …
Bai and Sosnick in 1995 (2), that the modern energy landscape theory of protein folding, by …
Fast-folding eriments and the topography of protein folding energy landscapes
The rapid folding of certain proteins can be described theoretically using an energy
landscape in the shape of a folding funnel. New techniques have allowed the examination of …
landscape in the shape of a folding funnel. New techniques have allowed the examination of …
Transition paths, diffusive processes, and preequilibria of protein folding
Z Zhang, HS Chan - … of the National Academy of Sciences, 2012 - National Acad Sciences
Fundamental relationships between the thermodynamics and kinetics of protein folding were
investigated using chain models of natural proteins with diverse folding rates by extensive …
investigated using chain models of natural proteins with diverse folding rates by extensive …
Protein folding in the landscape perspective: Chevron plots and non‐Arrhenius kinetics
We use two simple models and the energy landscape perspective to study protein folding
kinetics. A major challenge has been to use the landscape perspective to interpret …
kinetics. A major challenge has been to use the landscape perspective to interpret …
Using protein folding rates to test protein folding theories
B Gillespie, KW Plaxco - Annual review of biochemistry, 2004 - annualreviews.org
▪ Abstract The fastest simple, kinetically two-state protein folds a million times more rapidly
than the slowest. Here we review many recent theories of protein folding kinetics in terms of …
than the slowest. Here we review many recent theories of protein folding kinetics in terms of …
Behind the folding funnel diagram
M Karplus - Nature chemical biology, 2011 - nature.com
This Commentary clarifies the meaning of the funnel diagram, which has been widely cited
in papers on protein folding. To aid in the analysis of the funnel diagram, this Commentary …
in papers on protein folding. To aid in the analysis of the funnel diagram, this Commentary …
Two-state models of protein folding kinetics
R Zwanzig - Proceedings of the National Academy of …, 1997 - National Acad Sciences
The folding of some proteins appears to be a two-state kinetic process. A two-state kinetic
model is justified if protein molecules rapidly equilibrate between different unfolded …
model is justified if protein molecules rapidly equilibrate between different unfolded …
Protein folding rates and stability: how much is there beyond size?
An intriguing feature of protein folding is that the overall behavior obeys simple physical
rules, but the finer details show a great deal of complexity. The scaling of thermodynamic …
rules, but the finer details show a great deal of complexity. The scaling of thermodynamic …