Protein folding should be complex. Proteins organize themselves into specific three-
dimensional structures, through a myriad of conformational changes. The classical view of …

Publisher Summary This chapter presents an overview of the theoretical aspects of the “new
view” of protein folding based on the energy landscape theory and the funnel concept. The …

In recent years, improvements in experimental techniques and enhancements in computing
power have revolutionized our understanding of the mechanisms of protein folding. By …

There has been considerable progress made over the past year in linking experimental and
theoretical approaches to protein folding. Recent results from several independent lines of …

Our understanding of the principles underlying the protein-folding problem can be tested by
developing and characterizing simple models that make predictions which can be compared …

The protein-folding problem was first posed about one half-century ago. The term refers to
three broad questions:(i) What is the physical code by which an amino acid sequence …

The 'new view'of protein folding is based on a statistical analysis of the landscape for protein
folding. This perspective leads to the investigation of the statistical distributions of protein …

The understanding, and even the description of protein folding is impeded by the complexity
of the process. Much of this complexity can be described and understood by taking a …

▪ Abstract Beginning with simplified lattice and continuum “minimalist” models and
progressing to detailed atomic models, simulation studies have augmented and directed …

Recent experimental developments are changing the ways we interpret experimental data in
protein folding, leading to a closer connection with theory and an improved understanding of …