Synapse-specific structural plasticity that protects and refines local circuits during LTP and LTD

KM Harris, M Kuwajima… - Philosophical …, 2024 - royalsocietypublishing.org
Synapses form trillions of connections in the brain. Long-term potentiation (LTP) and long-
term depression (LTD) are cellular mechanisms vital for learning that modify the strength …

Activity-dependent diffusion trapping of AMPA receptors as a key step for expression of early LTP

A Nowacka, AM Getz… - Philosophical …, 2024 - royalsocietypublishing.org
This review focuses on the activity-dependent diffusion trapping of α-amino-3-hydroxy-5-
methyl-4-isoxazolepropionic acid receptors (AMPARs) as a crucial mechanism for the …

SHP2 regulates GluA2 tyrosine phosphorylation required for AMPA receptor endocytosis and mGluR-LTD

S Lee, J Kim, HH Ryu, H Jang… - Proceedings of the …, 2024 - National Acad Sciences
Posttranslational modifications regulate the properties and abundance of synaptic α-amino-
3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors that mediate fast excitatory …

A New Phase for WNK Kinase Signaling Complexes as Biomolecular Condensates

CR Boyd-Shiwarski, DJ Shiwarski… - Physiology, 2024 - journals.physiology.org
The purpose of this review is to highlight transformative advances that have been made in
the field of biomolecular condensates with special emphasis on condensate material …

Shifting rules in a brain disorder

D Choquet - Science, 2024 - science.org
The synaptic Ras/Rap guanosine triphosphatase (GTPase)–activating protein (SynGAP)
plays substantial, albeit still elusive, roles in synaptic function. SynGAP has attracted …

A structural role for SynGAP

D Yates - Nature Reviews Neuroscience, 2024 - nature.com
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