The purpose of this review is to highlight transformative advances that have been made in
the field of biomolecular condensates with special emphasis on condensate material …

The with no lysine (K)(WNK) kinases are an evolutionarily ancient group of kinases with
atypical placement of the catalytic lysine and diverse physiological roles. Recent studies …

When challenged by hypertonicity, dehydrated cells must recover their volume to survive.
This process requires the phosphorylation-dependent regulation of SLC12 cation chloride …

Abstract WNKs (with-no-lysine [K]) are a family of serine-threonine protein kinases with an
atypical placement of the catalytic lysine relative to all other protein kinases. The roles of …

Abstract WNK (With-No-Lysine (K)) kinases are serine–threonine kinases characterized by
an atypical placement of a catalytic lysine within the kinase domain. Mutations in human …

With-no-lysine (WNK) kinases coordinate volume and potassium homeostasis by regulating
renal tubular electrolyte transport. In the distal convoluted tubule (DCT), potassium …

The with-no-lysine (K) WNK kinases are master regulators of the Na+-(K+)-Cl−
cotransporters, including the renal-specific NCC and NKCC2 cotransporters. The discovery …

WNKs are serine/threonine kinases that comprise a unique branch of the kinome. They are
so-named owing to the unusual placement of an essential catalytic lysine. WNKs have now …

Hypokalemia contributes to the progression of chronic kidney disease, although a definitive
pathophysiological theory to explain this remains to be established. K+ deficiency results in …

Mutations in the serine-threonine kinases WNK1 and WNK4 cause a Mendelian disease
featuring hypertension and hyperkalemia. In vitro and in vivo studies have revealed that …