Interventions for reducing anticholinergic medication burden in older adults—a systematic review and meta-analysis

E Braithwaite, OM Todd, A Atkin, R Hulatt… - Age and …, 2023 - academic.oup.com
Introduction Anticholinergic medications block the neurotransmitter acetylcholine in the brain
and peripheral nervous system. Many medications have anticholinergic properties, and the …

The prognostic utility of anticholinergic burden scales: an integrative review and gap analysis

HU Michael, O Enechukwu, MJ Brouillette, R Tamblyn… - Drugs & Aging, 2023 - Springer
Background Anticholinergic drugs are commonly prescribed, especially to older adults.
Anticholinergic burden scales (ABS) have been used to evaluate the cumulative effects of …

Delirium‐associated medication in people at risk: A systematic update review, meta‐analyses, and GRADE‐profiles

M Reisinger, EZ Reininghaus, JD Biasi… - Acta Psychiatrica …, 2023 - Wiley Online Library
Background Drug‐associated delirium is a common but potentially preventable
neuropsychiatric syndrome associated with detrimental outcomes. Empirical evidence for …

Association of anticholinergic drug exposure with the risk of dementia among older adults in Japan: The LIFE Study

Y Okita, T Kitamura, S Komukai, L Zha… - … Journal of Geriatric …, 2023 - Wiley Online Library
Objectives Several studies have investigated that anticholinergic drugs cause cognitive
impairment. However, the risk of dementia associated with anticholinergics has not been …

Geriatricians, general internists, and potentially inappropriate medications for a national sample of older adults

JL Vandergrift, W Weng, B Leff… - Journal of the American …, 2024 - Wiley Online Library
Background Older adults are often prescribed medications that are potentially dangerous
and geriatricians have specialized training in treating polypharmacy that may benefit these …

Adherence to overactive bladder syndrome treatments recent developments and future perspectives

D Robinson, M O'Kane, L Cardozo - International Journal of …, 2023 - Taylor & Francis
Overactive bladder (OAB) is a common and distressing condition which is known to have a
significant effect on Health-Related Quality of Life (HRQoL). Whilst all patients complaining …

Frequency and clinical impact of anticholinergic burden in older patients: comparing older patients with and without chronic kidney disease

S Yildiz, C Heybeli, P Soysal, L Smith… - Archives of Gerontology …, 2023 - Elsevier
Aim This study aimed to determine the frequency and impact of anticholinergic burden in
older adults with chronic kidney disease (CKD) and compare the results to older adults …

Factors influencing central nervous system medication deprescribing and behavior change in hospitalized older adults

JM Pavon, AD Zhang, LJ Fish… - Journal of the …, 2024 - Wiley Online Library
Background Central nervous system (CNS) medications are linked to higher morbidity and
mortality in older adults. Hospitalization allows for deprescribing opportunities. This …

A pilot study investigating cognitive impairment associated with opioid overdose

JJ Mahoney III, EL Winstanley, F Castillo… - Drug and alcohol …, 2023 - Elsevier
Background In 2021, while overdose (OD) deaths were at the highest in recorded history, it
is estimated that> 80% of ODs do not result in a fatality. While several case studies have …

Longitudinal post-shunt outcomes in idiopathic normal pressure hydrocephalus with and without comorbid Alzheimer's disease

D Gold, C Wisialowski, I Piryatinsky… - Journal of the …, 2023 - cambridge.org
Objective: Alzheimer's disease (AD) is highly comorbid with idiopathic normal pressure
hydrocephalus (iNPH) and may diminish the benefits of shunting; however, findings in this …