Abstract The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal
transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell …

Many cellular processes in cancer are attributed to kinase signaling networks. V-akt murine
thymoma viral oncogene homolog (AKT) plays a major role in the PI3K/AKT signaling …

The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide
gene. Achieving the same using small molecules would have a tremendous impact on …

The molecular mechanisms of cellular insulin action have been the focus of much
investigation since the discovery of the hormone 100 years ago. Insulin action is impaired in …

The phosphatidylinositol-3-kinase (PI3K)/Akt and the mammalian target of rapamycin
(mTOR) signaling pathways are two pathways crucial to many aspects of cell growth and …

One signal that is overactivated in a wide range of tumour types is the production of a
phospholipid, phosphatidylinositol (3, 4, 5) trisphosphate, by phosphatidylinositol 3-kinase …

Akt is a serine/threonine kinase and it participates in the key role of the PI3K signaling
pathway. The Akt can be activated by a wide range of growth signals and the biochemical …

▪ Abstract Neurotrophins regulate development, maintenance, and function of vertebrate
nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of …

Apoptosis and necrosis are the two major modes of cell death, the molecular mechanisms of
which have been extensively studied. Although initially thought to constitute mutually …

(Hunter, 1998). RTKs play an important role in the control 1998; Jiang and Hunter, 1999).
Receptor dimerization is of most fundamental cellular processes including the further …