Breast cancer is a serious health problem worldwide, representing the second cause of
death through malignancies among women in developed countries. Population …

Abstract The PI3 K/AKT/mTOR signalling pathway plays an important role in the regulation of
signal transduction and biological processes such as cell proliferation, apoptosis …

Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The
uptake and metabolism of amino acids are aberrantly upregulated in many cancers that …

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic interstitial pneumonia
with unknown causes. The incidence rate increases year by year and the prognosis is poor …

Arsenic, a metalloid and naturally occurring element, is one of the most abundant elements
in the earth's crust. Water is contaminated by arsenic through natural sources (underground …

Circular RNAs (circRNAs), covalently closed noncoding RNAs, are widely expressed in
eukaryotes and viruses. They can function by regulating target gene expression, linear RNA …

Polyphenols constitute an important group of natural products that are traditionally
associated with a wide range of bioactivities. These are usually found in low concentrations …

In recent years, accumulating evidence has elucidated the role of lysosomes in dynamically
regulating cellular and organismal homeostasis. Lysosomal changes and dysfunction have …

Diabetic nephropathy is one of the most common complications in diabetes. It has been
shown to be the leading cause of end-stage renal disease. However, due to their complex …

Flavonoids represent an important group of bioactive compounds derived from plant-based
foods and beverages with known biological activity in cells. From the modulation of …