Transplantation of adult bone marrow–derived mesenchymal stem cells has been proposed
as a strategy for cardiac repair following myocardial damage. However, poor cell viability …

The nuclear factor kB (NF-kB) comprises a family of transcription factors involved in the
regulation of a wide variety of biological responses. NF-kB plays a well-known function in …

▪ Abstract Nerve growth factor (NGF) was discovered 50 years ago as a molecule that
promoted the survival and differentiation of sensory and sympathetic neurons. Its roles in …

Recent studies suggest that statins can function to protect the vasculature in a manner that is
independent of their lipid-lowering activity. We show here that statins rapidly activate the …

VEGFs (vascular endothelial growth factors) control vascular development during
embryogenesis and the function of blood vessels and lymphatic vessels in the adult. There …

The serine/threonine kinase Akt lies at a critical signaling node downstream of
phosphatidylinositol-3-kinase and is important in promoting cell survival and inhibiting …

In patients with chronic kidney disease (CKD), loss of cellular proteins increases the risks of
morbidity and mortality. Persistence of muscle protein catabolism in CKD results in striking …

Reactive oxygen species (ROS) are a byproduct of normal metabolism and have roles in cell
signaling and homeostasis. Species include oxygen radicals and reactive nonradicals …

Recent research has examined Akt and Akt-related serine–threonine kinases in signaling
cascades that regulate cell survival and are important in the pathogenesis of degenerative …

Background: Gefitinib is a selective inhibitor of the epidermal growth factor (EGFR) tyrosine
kinase, which is overexpressed in many cancers, including non–small-cell lung cancer …