CDH1

CDH1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1O6S, 2O72, 2OMT, 2OMU, 2OMV, 2OMX, 2OMY, 2OMZ, 3FF7, 3FF8, 3L6X, 3L6Y, 4ZT1, 4ZTE
Dynodwyr
Cyfenwau	CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO, cadherin 1, BCDS1, E-cadherin, uvomorulin
Dynodwyr allanol	OMIM: 192090 HomoloGene: 20917 GeneCards: CDH1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• calcium ion binding; • GO:0001948, GO:0016582 protein binding; • ankyrin binding; • gamma-catenin binding; • beta-catenin binding; • GTPase activating protein binding; • metal ion binding; • cell adhesion molecule binding; • cadherin binding; • identical protein binding; • cytoskeletal protein binding; • protein homodimerization activity;
Cydrannau o'r gell	• apical junction complex; • trans-Golgi network; • extracellular region; • perinuclear region of cytoplasm; • cortical actin cytoskeleton; • Golgi apparatus; • lamellipodium; • cytoplasmic side of plasma membrane; • endosome; • lateral plasma membrane; • catenin complex; • actin cytoskeleton; • flotillin complex; • bilen; • extracellular exosome; • integral component of membrane; • cell junction; • cytoplasm; • Cellbilen; • cell surface; • postsynapse; • glutamatergic synapse;
Prosesau biolegol	• negative regulation of cell-cell adhesion; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • cellular response to lithium ion; • cell adhesion; • extracellular matrix organization; • cellular response to indole-3-methanol; • extracellular matrix disassembly; • synapse assembly; • pituitary gland development; • response to toxic substance; • response to organic substance; • neuron projection development; • adherens junction organization; • homophilic cell adhesion via plasma membrane adhesion molecules; • entry of bacterium into host cell; • protein localization to plasma membrane; • cell-cell adhesion; • GO:0000767 cell morphogenesis; • cell-cell junction assembly; • regulation of gene expression; • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; • negative regulation of cell migration; • positive regulation of protein import into nucleus; • cell-cell adhesion mediated by cadherin; • regulation of protein catabolic process at postsynapse, modulating synaptic transmission;
	Sources:Amigo / QuickGO
Orthologau
	999
	n/a
	ENSG00000039068
	n/a
	P12830
	n/a
	NM_004360; NM_001317184; NM_001317185; NM_001317186
	n/a
	NP_001304113; NP_001304114; NP_001304115; NP_004351
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CDH1 yw CDH1 a elwir hefyd yn Cadherin 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16q22.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CDH1.

UVO
CDHE
ECAD
LCAM
Arc-1
BCDS1
CD324

Llyfryddiaeth

"Influence of autocrine growth hormone on NF-κB activation leading to epithelial-mesenchymal transition of mammary carcinoma. ". Tumour Biol. 2017. PMID 29022487.
"E-cadherin: A determinant molecule associated with ovarian cancer progression, dissemination and aggressiveness. ". PLoS One. 2017. PMID 28934230.
"Expression and potential roles of sodium-potassium ATPase and E-cadherin in human gastric adenocarcinoma. ". PLoS One. 2017. PMID 28832634.
"E-cadherin expression increases cell proliferation by regulating energy metabolism through nuclear factor-κB in AGS cells. ". Cancer Sci. 2017. PMID 28699254.
"Linking E-cadherin mechanotransduction to cell metabolism through force-mediated activation of AMPK.". Nat Cell Biol. 2017. PMID 28553939.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CDH1 - Cronfa NCBI

[1]

[2]