5. Introduction to different dosage form part 5.ppt

INTRODUCTION TO
DIFFERENT DOSAGE
FORMS
Presented by:
Mr. Parimal Hadge
Datta Meghe Institute of Medical Science(DU)
Salod(H);Sawangi(M); Wardha:

Learning objectives:
The learner will be able to learn:
• Different types of dosage form
• Needs of dosage form
• Detail account on Monophasic Liquid dosage form

Monophasic liquid dosage forms
for Internal Use

Linctuses
These are viscous liquid preparations
that’s are used for the treatment of cough.
They contain medicaments which have
demulcent, sedative, expectorant action.
They are taken in small doses without
diluting with water to have prolonged
effect of medicines.
Simple syrup is used as a vehicle for most
of the linctuses.
Tolu syrup is preferred in certain cases
because of its aromatic odour & flavour.
Moreover it have a mild expectorant action

Drops
These are liquid preparations meant for oral administration.
The oil soluble vitamins, such as vitamin A & D concentrates
in fish – liver oil are presented as drops for administration.
Since these preparations contain potent medicaments, the
dose must be measured accurately
The following two methods are commonly used for this
purpose.
Use of a dropper which is accurately graduated in fractions
of a milliliters.
Use of a pre – calibrated dropper.

Monophasic liquid dosage
forms for External use

Liniments
Liniments are liquid or semi- liquid preparations
meant for external application to the skin.
They are usually applied to the skin with friction &
rubbing of the skin.
Are usually alcoholic and oily liquid preparations
(monophasic) or emulsion (biphasic).
Alcoholic liniments are used generally for their
rubefacient and counterirritant effects. Such
liniments penetrate the skin more readily than do
those with an oil base.
 The oily liniments are milder in their action and
may function solely as protective coatings
 Liniments should not be applied to skin that are
bruised or broken.

Lotions
 Are usually aqueous, alcoholic or oily liquid
preparations.
 They are intended for external application
without friction or rubbing to the affected area
Usually applied with the help of some
absorbent material such as cotton wool or
gauze.
It is generally used to provide cooling, soothing
and protective & antiseptic action.

Gargles
Gargles are aqueous solutions used for treating throat
infection (pharynx and nasopharynx part)
 Supplied in concentrated forms with directions of dilution
with warm water before use
They are used into intimate contact with the mucous
membrane of throat for few seconds, before they are
thrown out of the mouth.
They are used to relieve soreness in mild throat infection.
They are also used for their antiseptics, antibiotics and/or
anesthetics

Mouth Wash
These are aqueous solutions with
pleasant or acceptable taste &
odour
These are used to make clean &
deodorise the buccal cavity or used
for oral hygiene and to treat
infections of the mouth.
They mainly contain antibacterial
agent, alcohol, glycerin,
sweetening agent, flavoring agent
& colouring agent.

Throat Paints
Throat paints are viscous liquid
preparations used for mouth and
throat infections
Glycerin is commonly used as a
base because being viscous it
adheres to mucous membrane for
long period and it possess a sweet
taste.

Sprayes
These are the preparations of drugs in media
which may be aqueous, alcoholic, or glycerin.
They are applied to the mucous membrane of
throat or nose with an atomizer.
The throat sprays must be sprayed from a
special type of atomizer known as a nebulizer,
which removes the large droplets by baffling
system. Only precaution should be taken that
the fine droplet will used to easily reach the
lungs.

Inhalations
These are liquid preparations containing volatile substance
& are used to relieve decongestion & inflammations of
respiratory tract.
The volatile substance in inhalations would be volatile at
room temperature so that they should be placed on some
adsorbent pad or handkerchief.
In some cases inhalations will added to hot water (650c)
then vapors will inhaled.

Nasal Dropes
Drugs in solution may be instilled into the nose from a dropper
or from a plastic squeeze bottle.
The drug may have a local effect, e.g. antihistamine,
decongestant.
Alternatively the drug may be absorbed through the nasal
mucosa to exert a systemic effect.
The use of oily nasal drops should be avoided because of
possible damage to the cilia of the nasal mucosa & if it is used
for long period may reach the lungs & cause lipoid pneumonia.
To avoid that Nasal drops are prepared so that they are similar
in many respects to nasal secretions, so that normal ciliary
action is maintained thus aqueous nasal solutions usually are
isotonic and slightly buffered to maintain a pH of 5.5 to 6.5.

Eye Dropes
Sterile, aqueous/oily solutions or suspensions intended for
instillation in eye sac.
Eye drops may contain buffers, stabilizing agents, dispersing
agents, solubilising agents, anti-oxidants & agents required
for tonicity/ viscosity adjustment
Single dose container should not contain anti-microbial
preservative.
 In case of multi dose container a dropper should be
supplied with it for administration. Maximum size of such
containers is 10 ml.

Eye Lotions
These are the aqueous solutions used for washing the eyes.
These are supplied in concentrated forms & are required to
diluted with warm water immediately before use.
They should be free from foreign particles to avoids
irritation to the eye.
They are required to prepared fresh & should not be stored
for more than two days to avoid microbial contaminations.

Ear Dropes
These are the solutions of drugs that are instilled into ear
cavity with the help of dropper.
These are generally used for cleaning the ear, softening the
wax & for treating the mild infections.
The solutions is generally prepared in water, glycerin,
propylene glycol & dilute alcohol.

References:
• R. M. Mehta text book for pharmaceutics I
• Lachman, A reference book for pharmaceutics
• Martin, A reference book for pharmaceutics

5. Introduction to different dosage form part 5.ppt

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