Heterogeneity in kinesin function
The kinesin family proteins are often studied as prototypical molecular motors; a deeper
understanding of them can illuminate regulation of intracellular transport. It is typically …
understanding of them can illuminate regulation of intracellular transport. It is typically …
A mechanistic study of helicases with magnetic traps
Helicases are a broad family of enzymes that separate nucleic acid double strand structures
(DNA/DNA, DNA/RNA, or RNA/RNA) and thus are essential to DNA replication and the …
(DNA/DNA, DNA/RNA, or RNA/RNA) and thus are essential to DNA replication and the …
Cellular Adaptation Relies on Regulatory Proteins Having Episodic Memory: Proteins Modulate Cell Metabolism and Reproduction by Remembering, Transmitting …
The ability to memorize changes in the environment is present at all biological levels, from
social groups and individuals, down to single cells. Trans‐generational memory is …
social groups and individuals, down to single cells. Trans‐generational memory is …
Allosteric ring assembly and chemo-mechanical melting by the interaction between 5′-phosphate and λ exonuclease
J Yoo, G Lee - Nucleic acids research, 2015 - academic.oup.com
Phosphates along the DNA function as chemical energy frequently used by nucleases to
drive their enzymatic reactions. Exonuclease functions as a machine that converts chemical …
drive their enzymatic reactions. Exonuclease functions as a machine that converts chemical …
A physicist's view of DNA
A Mashaghi, A Katan - arXiv preprint arXiv:1311.2545, 2013 - arxiv.org
Nucleic acids, like DNA and RNA, are molecules that are present in any life form. Their most
notable function is to encode biological information. Why then would a physicist be …
notable function is to encode biological information. Why then would a physicist be …
The noisy and marvelous molecular world of biology
F Ritort - Inventions, 2019 - mdpi.com
At the molecular level biology is intrinsically noisy. The forces that regulate the myriad of
molecular reactions in the cell are tiny, on the order of piconewtons (10− 12 Newtons), yet …
molecular reactions in the cell are tiny, on the order of piconewtons (10− 12 Newtons), yet …
Single-molecule studies of helicases and translocases in prokaryotic genome-maintenance pathways
Helicases involved in genomic maintenance are a class of nucleic-acid dependent ATPases
that convert the energy of ATP hydrolysis into physical work to execute irreversible steps in …
that convert the energy of ATP hydrolysis into physical work to execute irreversible steps in …
Direct unfolding of RuvA-HJ complex at the single-molecule level
The repair of double-stranded DNA breaks via homologous recombination involves a four-
way cross-strand intermediate known as Holliday junction (HJ), which is recognized …
way cross-strand intermediate known as Holliday junction (HJ), which is recognized …
Nonequilibrium work relations for energy and information
F Ritort - arXiv preprint arXiv:2404.04582, 2024 - arxiv.org
arXiv:2404.04582v1 [physics.bio-ph] 6 Apr 2024 Page 1 Nonequilibrium work relations for
energy and information Felix Ritort∗ Small Biosystems Lab, Condensed Matter Physics …
energy and information Felix Ritort∗ Small Biosystems Lab, Condensed Matter Physics …
Fluidic switching in nanochannels for the control of Inchworm: a synthetic biomolecular motor with a power stroke
CS Niman, MJ Zuckermann, M Balaz, JO Tegenfeldt… - Nanoscale, 2014 - pubs.rsc.org
Synthetic molecular motors typically take nanometer-scale steps through rectification of
thermal motion. Here we propose Inchworm, a DNA-based motor that employs a …
thermal motion. Here we propose Inchworm, a DNA-based motor that employs a …