The role of brain derived neurotrophic factor in central nervous system

Y Li, F Li, D Qin, H Chen, J Wang, J Wang… - Frontiers in Aging …, 2022 - frontiersin.org
Brain derived neurotrophic factor (BDNF) has multiple biological functions which are
mediated by the activation of two receptors, tropomyosin receptor kinase B (TrkB) receptor …

Brain-derived neurotropic factor in neurodegenerative disorders

AM Ibrahim, L Chauhan, A Bhardwaj, A Sharma… - Biomedicines, 2022 - mdpi.com
Globally, neurodegenerative diseases cause a significant degree of disability and distress.
Brain-derived neurotrophic factor (BDNF), primarily found in the brain, has a substantial role …

Brain-derived neurotrophic factor: a novel dynamically regulated therapeutic modulator in neurological disorders

V Sharma, TG Singh, A Kaur, A Mannan… - Neurochemical …, 2023 - Springer
The growth factor brain-derived neurotrophic factor (BDNF), and its receptor tropomyosin-
related kinase receptor type B (TrkB) play an active role in numerous areas of the adult …

Potential therapeutic uses of BDNF in neurological and psychiatric disorders

AH Nagahara, MH Tuszynski - Nature reviews Drug discovery, 2011 - nature.com
The growth factor brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-
related kinase receptor type B (TRKB) are actively produced and trafficked in multiple …

Actions of brain-derived neurotrophin factor in the neurogenesis and neuronal function, and its involvement in the pathophysiology of brain diseases

T Numakawa, H Odaka, N Adachi - International journal of molecular …, 2018 - mdpi.com
It is well known that brain-derived neurotrophic factor, BDNF, has an important role in a
variety of neuronal aspects, such as differentiation, maturation, and synaptic function in the …

Neurotrophic factor BDNF, physiological functions and therapeutic potential in depression, neurodegeneration and brain cancer

L Colucci-D'Amato, L Speranza, F Volpicelli - International journal of …, 2020 - mdpi.com
Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …

Brain-derived neurotrophic factor as a drug target for CNS disorders

S Pezet, M Malcangio - Expert opinion on therapeutic targets, 2004 - Taylor & Francis
Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family of trophic
factors. BDNF is widely and abundantly expressed in the CNS and is available to some …

The role of brain-derived neurotrophic factor signaling in central nervous system disease pathogenesis

SH Dou, Y Cui, SM Huang, B Zhang - Frontiers in Human …, 2022 - frontiersin.org
Recent studies have found abnormal levels of brain-derived neurotrophic factor (BDNF) in a
variety of central nervous system (CNS) diseases (eg, stroke, depression, anxiety …

Brain derived neurotrophic factor: a novel neurotrophin involved in psychiatric and neurological disorders

S Balaratnasingam, A Janca - Pharmacology & therapeutics, 2012 - Elsevier
Brain Derived Neurotrophic Factor (BDNF) is a unique member of the neurotrophin family
with potent and plethoric effects on the proliferation, differentiation, survival and death of …

Recent advances on the role of brain-derived neurotrophic factor (BDNF) in neurodegenerative diseases

KF Azman, R Zakaria - International journal of molecular sciences, 2022 - mdpi.com
Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are essential for neuronal
survival and growth. The signaling cascades initiated by BDNF and its receptor are the key …