Translational evidence for a role of endocannabinoids in the etiology and treatment of posttraumatic stress disorder

A Neumeister, J Seidel, BJ Ragen… - Psychoneuroendocrinology, 2015 - Elsevier
Introduction Posttraumatic stress disorder (PTSD) is a prevalent, chronic, and disabling
anxiety disorder that may develop following exposure to a traumatic event. Despite the …

Toward a translational approach to targeting the endocannabinoid system in posttraumatic stress disorder: a critical review of preclinical research

S Papini, GM Sullivan, DA Hien, E Shvil, Y Neria - Biological Psychology, 2015 - Elsevier
Despite the lack of clinical research, marijuana and synthetic cannabinoids have been
approved to treat posttraumatic stress disorder (PTSD) in several states in the United States …

Cannabinoids as therapeutics for PTSD

B Sbarski, I Akirav - Pharmacology & therapeutics, 2020 - Elsevier
Post-traumatic stress disorder (PTSD) is a complex disorder that involves dysregulation of
multiple neurobiological systems. The traumatic stressor plays a causal role in producing …

Modulation of the endocannabinoid system by sex hormones: Implications for posttraumatic stress disorder

LJ Ney, A Matthews, R Bruno… - … & Biobehavioral Reviews, 2018 - Elsevier
The endocannabinoid system is an increasingly recognised pharmacological target for
treating stress and anxiety disorders, including post-traumatic stress disorder (PTSD) …

Integrating endocannabinoid signaling and cannabinoids into the biology and treatment of posttraumatic stress disorder

MN Hill, P Campolongo, R Yehuda… - …, 2018 - nature.com
Exposure to stress is an undeniable, but in most cases surmountable, part of life. However,
in certain individuals, exposure to severe or cumulative stressors can lead to an array of …

The endocannabinoid system as a possible target to treat both the cognitive and emotional features of post-traumatic stress disorder (PTSD)

V Trezza, P Campolongo - Frontiers in behavioral neuroscience, 2013 - frontiersin.org
Post-traumatic stress disorder (PTSD) is a psychiatric disorder of significant prevalence and
morbidity, whose pathogenesis relies on paradoxical changes of emotional memory …

[HTML][HTML] Targeting the endocannabinoid system to treat anxiety-related disorders

N Korem, TM Zer-Aviv, E Ganon-Elazar… - Journal of basic and …, 2016 - degruyter.com
The endocannabinoid system plays an important role in the control of emotions, and its
dysregulation has been implicated in several psychiatric disorders. The most common self …

RETRACTED ARTICLE: Cannabinoid Type 1 Receptor Availability in the Amygdala Mediates Threat Processing in Trauma Survivors

RH Pietrzak, Y Huang, S Corsi-Travali… - …, 2014 - nature.com
Attentional bias to threat is a key endophenotype that contributes to the chronicity of trauma-
related psychopathology. However, little is known about the neurobiology of this …

[HTML][HTML] Targeting the endocannabinoid system in the treatment of posttraumatic stress disorder: A promising case of preclinical-clinical translation?

LM Mayo, CA Rabinak, MN Hill, M Heilig - Biological psychiatry, 2022 - Elsevier
The endocannabinoid (eCB) system is one the most ubiquitous signaling systems of the
brain and offers a rich pharmacology including multiple druggable targets. Preclinical …

Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study

A Neumeister, MD Normandin, RH Pietrzak… - Molecular …, 2013 - nature.com
Endocannabinoids and their attending cannabinoid type 1 (CB 1) receptor have been
implicated in animal models of post-traumatic stress disorder (PTSD). However, their specific …