Exploiting the multifaceted effects of cannabinoids on mood to boost their therapeutic use against anxiety and depression
M Stampanoni Bassi, L Gilio, P Maffei… - Frontiers in Molecular …, 2018 - frontiersin.org
The endocannabinoid system (ECS) has been recently recognized as a prominent promoter
of the emotional homeostasis, mediating the effects of different environmental signals …
of the emotional homeostasis, mediating the effects of different environmental signals …
The endocannabinoid system in mental disorders: Evidence from human brain studies
I Ibarra-Lecue, F Pilar-Cuéllar, C Muguruza… - Biochemical …, 2018 - Elsevier
Mental disorders have a high prevalence compared with many other health conditions and
are the leading cause of disability worldwide. Several studies performed in the last years …
are the leading cause of disability worldwide. Several studies performed in the last years …
Circulating endocannabinoids and psychological outcomes in women with PTSD
C Botsford, AG Brellenthin, JM Cisler, CJ Hillard… - Journal of anxiety …, 2023 - Elsevier
Background Recent research has attempted to elucidate the relationship between blood-
based biomarkers (eg, endocannabinoids; eCBs: including N-arachidonoylethanolamine …
based biomarkers (eg, endocannabinoids; eCBs: including N-arachidonoylethanolamine …
The therapeutic potential of the endocannabinoid system for the development of a novel class of antidepressants
The endocannabinoid system is a neuromodulatory system which is known to regulate
emotional, cognitive, neurovegetative and motivational processes. Substantial evidence has …
emotional, cognitive, neurovegetative and motivational processes. Substantial evidence has …
The effects of enhancing endocannabinoid signaling and blocking corticotrophin releasing factor receptor in the amygdala and hippocampus on the consolidation of a …
Current clinical and pre-clinical data suggest that both cannabinoid agents and blockage of
CRF through corticotrophin releasing factor receptor type 1 (CRFr1) may offer therapeutic …
CRF through corticotrophin releasing factor receptor type 1 (CRFr1) may offer therapeutic …
Endocannabinoid signals in the control of emotion
B Lutz - Current opinion in pharmacology, 2009 - Elsevier
The appropriate control of emotional responses evoked by environmental stimuli is an
important innate mechanism for ensuring quality of life and even for survival. Inappropriate …
important innate mechanism for ensuring quality of life and even for survival. Inappropriate …
Pharmacotherapeutic modulation of the endocannabinoid signalling system in psychiatric disorders: drug-discovery strategies
DR Janero, SK Vadivel… - International Review of …, 2009 - Taylor & Francis
Medicinal chemistry has produced small-molecule agents with drug-like character that
potently and safely modulate the activity of discrete endocannabinoid system components …
potently and safely modulate the activity of discrete endocannabinoid system components …
Cannabinoid receptor activation prevents the effects of chronic mild stress on emotional learning and LTP in a rat model of depression
Most psychiatric disorders are characterized by emotional memory or learning disturbances.
Chronic mild stress (CMS) is a common animal model for stress-induced depression. Here …
Chronic mild stress (CMS) is a common animal model for stress-induced depression. Here …
High times for painful blues: the endocannabinoid system in pain-depression comorbidity
Depression and pain are two of the most debilitating disorders worldwide and have an
estimated cooccurrence of up to 80%. Comorbidity of these disorders is more difficult to treat …
estimated cooccurrence of up to 80%. Comorbidity of these disorders is more difficult to treat …
Endocannabinoid system in psychotic and mood disorders, a review of human studies
Despite widespread evidence of endocannabinoid system involvement in the
pathophysiology of psychiatric disorders, our understanding remains rudimentary. Here we …
pathophysiology of psychiatric disorders, our understanding remains rudimentary. Here we …