Proteins appear to fold by diverse pathways, but variations of a simple mechanism–
nucleation-condensation–describe the overall features of folding of most domains. In …

Two fundamentally different views of how proteins fold are now being debated. Do proteins
fold through multiple unpredictable routes directed only by the energetically downhill nature …

The description of protein folding mechanisms in terms of the structures of well defined,
partially folded intermediates is a major objective in structural biology. Despite the fleeting …

The functional requirement to form and maintain the active site structure probably exerts a
strong selective pressure on a protein to adopt just one stable and evolutionarily conserved …

Experimental and theoretical studies together are providing insights into the mechanism by
which proteins fold. Our present knowledge of the essential aspects of the folding reaction is …

Over the past 25 years, enormous breakthroughs have been made in understanding protein
folding mechanisms. We have now reached an exciting stage, with consensuses beginning …

The genome project, with the discovery of thousands of new protein sequences every year,
has created a revolution in protein physics, chemistry, and biology. This has led to a …

During the past year, advances in our understanding of folding mechanisms have been
made through detailed experimental and theoretical studies of a number of proteins. The …

Investigators have recently turned to studies of protein families to shed light on the
mechanism of protein folding. In small proteins for which detailed analysis has been …

The field of protein folding now offers considerable excitement. Comparative studies of the
transition-state structures for a series of protein families with analogous structures have …