Frailty is the most problematic expression of population ageing. It is a state of vulnerability to
poor resolution of homoeostasis after a stressor event and is a consequence of cumulative …

Objectives: to determine the effect of drugs with anti-cholinergic properties on relevant
health outcomes. Design: electronic published and unpublished literature/trial registries …

Background Mild cognitive impairment (MCI) increases dementia risk with no pharmacologic
treatment available. Methods The Study of Mental and Resistance Training was a …

Objectives Investigations of exercise and cognition have primarily focused on healthy or
demented older adults, and results have been equivocal in individuals with mild cognitive …

Background: frailty is a state of vulnerability to stressor events. There is uncertainty about the
beneficial effects of exercise interventions for older people with frailty. The Home-based …

Objective: To investigate the relation between physical exercise and the microstructural
integrity of cerebral white matter. Methods: Four hundred forty individuals with cerebral small …

Introduction Despite the beneficial effects of physical activity (PA) for people with mild
cognitive impairment (MCI) on cognition and the acknowledgement that MCI is a critical …

This meta-analysis examined how performance on various cognitive domains of
neuropsychological functioning can contribute to predicting progression to dementia from …

Background and Purpose: Cerebral small vessel disease (CSVD) is a common subclinical
feature of the aging brain. Steps per day may contribute to its prevention. We herein …

Study Objectives To evaluate the association between anticholinergic medication use,
categorized by anticholinergic cognitive burden (primary objective) and cumulative dose …