With the ageing of the global population, interest is growing in the 'geroscience hypothesis',
which posits that manipulation of fundamental ageing mechanisms will delay (in parallel) the …

The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …

Alzheimer's disease (AD) is the most common neurodegenerative disease among the
elderly with a progressive decline in cognitive function significantly affecting quality of life …

Ageing-associated functional decline of organs and increased risk for age-related chronic
pathologies is driven in part by the accumulation of senescent cells, which develop the …

A robust and heterogenous secretory phenotype is a core feature of most senescent cells. In
addition to mediators of age‐related pathology, components of the senescence associated …

Importance Longitudinal associations between comorbid depression and anxiety with the
accumulation of chronic illnesses are unclear, and questions remain about the contributions …

Background No clear synthesis of evidence examining household and area-level social
determinants of multimorbidity exists. This study aimed to systematically review the existing …

Introduction Recent advances in generating massive single‐cell/nucleus transcriptomic data
have shown great potential for facilitating the identification of cell type–specific Alzheimer's …

Background Multimorbidity is increasing among older adults, but the impact of these recent
trends on the extent and complexity of polypharmacy and possible variation by sex remains …

Alzheimer's disease is the leading cause of dementia worldwide and is characterized by a
long preclinical phase in which amyloid-β and tau accumulate in the absence of cognitive …