Neurotrophic factor BDNF, physiological functions and therapeutic potential in depression, neurodegeneration and brain cancer
Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …
BDNF: a key factor with multipotent impact on brain signaling and synaptic plasticity
P Kowiański, G Lietzau, E Czuba, M Waśkow… - Cellular and molecular …, 2018 - Springer
Brain-derived neurotrophic factor (BDNF) is one of the most widely distributed and
extensively studied neurotrophins in the mammalian brain. Among its prominent functions …
extensively studied neurotrophins in the mammalian brain. Among its prominent functions …
Sleep deprivation and neurological disorders
Sleep plays an important role in maintaining neuronal circuitry, signalling and helps
maintain overall health and wellbeing. Sleep deprivation (SD) disturbs the circadian …
maintain overall health and wellbeing. Sleep deprivation (SD) disturbs the circadian …
[HTML][HTML] Long-term potentiation and memory
MA Lynch - Physiological reviews, 2004 - journals.physiology.org
Abstract Lynch, MA. Long-Term Potentiation and Memory. Physiol Rev 84: 87–136, 2004;
10.1152/physrev. 00014.2003.—One of the most significant challenges in neuroscience is to …
10.1152/physrev. 00014.2003.—One of the most significant challenges in neuroscience is to …
The induction of pain: an integrative review
MJ Millan - Progress in neurobiology, 1999 - Elsevier
The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …
Function and regulation of CREB family transcription factors in the nervous system
BE Lonze, DD Ginty - Neuron, 2002 - cell.com
CREB and its close relatives are now widely accepted as prototypical stimulus-inducible
transcription factors. In many cell types, these factors function as effector molecules that …
transcription factors. In many cell types, these factors function as effector molecules that …
CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals
AJ Shaywitz, ME Greenberg - Annual review of biochemistry, 1999 - annualreviews.org
▪ Abstract Extracellular stimuli elicit changes in gene expression in target cells by activating
intracellular protein kinase cascades that phosphorylate transcription factors within the …
intracellular protein kinase cascades that phosphorylate transcription factors within the …
HDAC2 negatively regulates memory formation and synaptic plasticity
JS Guan, SJ Haggarty, E Giacometti, JH Dannenberg… - Nature, 2009 - nature.com
Chromatin modifications, especially histone-tail acetylation, have been implicated in
memory formation. Increased histone-tail acetylation induced by inhibitors of histone …
memory formation. Increased histone-tail acetylation induced by inhibitors of histone …
Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
Huntington's disease is caused by an abnormal polyglutamine expansion within the protein
huntingtin and is characterized by microscopic inclusion bodies of aggregated huntingtin …
huntingtin and is characterized by microscopic inclusion bodies of aggregated huntingtin …
Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition
S Vaynman, Z Ying… - European Journal of …, 2004 - Wiley Online Library
We found that a short exercise period enhanced cognitive function on the Morris water maze
(MWM), such that exercised animals were significantly better than sedentary controls at …
(MWM), such that exercised animals were significantly better than sedentary controls at …