The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …

With the ageing of the global population, interest is growing in the 'geroscience hypothesis',
which posits that manipulation of fundamental ageing mechanisms will delay (in parallel) the …

Ageing-associated functional decline of organs and increased risk for age-related chronic
pathologies is driven in part by the accumulation of senescent cells, which develop the …

Importance The prevalence of cardiometabolic multimorbidity is increasing. Objective To
estimate reductions in life expectancy associated with cardiometabolic multimorbidity …

Remodelling of the immune system with age—immunosenescence—is a substantial
contributor to poor health in older adults, with increasing risk of infections, cancer and …

Background Multimorbidity, the co-occurrence of two or more chronic conditions, is common
among older adults and is known to be associated with high costs and gaps in quality of …

Multimorbidity occurs in adults of all ages, but the number and complexity of comorbid
conditions commonly increase with advancing age such that cardiovascular disease (CVD) …

Aging is characterized by rising susceptibility to development of multiple chronic diseases
and, therefore, represents the major risk factor for multimorbidity. From a gerontological …

Importance A National Institute on Aging and Alzheimer's Association workgroup proposed a
research framework for Alzheimer disease in which biomarker classification of research …

Alzheimer's disease (AD) is the most common neurodegenerative disease among the
elderly with a progressive decline in cognitive function significantly affecting quality of life …