Authors
Gaël Chételat, Victor L Villemagne, Pierrick Bourgeat, Kerryn E Pike, Gareth Jones, David Ames, Kathryn A Ellis, Cassandra Szoeke, Ralph N Martins, Graeme J O'Keefe, Olivier Salvado, Colin L Masters, Christopher C Rowe, Australian Imaging Biomarkers and Lifestyle Research Group
Publication date
2010/3
Journal
Annals of neurology
Volume
67
Issue
3
Pages
317-324
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Description
Objective
Elucidating the role of aggregated β‐amyloid in relation to gray matter atrophy is crucial to the understanding of the pathological mechanisms of Alzheimer disease and for the development of therapeutic trials. The present study aims to assess this relationship.
Methods
Brain magnetic resonance imaging and [11C]Pittsburgh compound B (PiB)‐positron emission tomography scans were obtained from 94 healthy elderly subjects (49 with subjective cognitive impairment), 34 patients with mild cognitive impairment, and 35 patients with Alzheimer disease. The correlations between global and regional neocortical PiB retention and atrophy were analyzed in each clinical group.
Results
Global and regional atrophy were strongly related to β‐amyloid load in participants with subjective cognitive impairment but not in patients with mild cognitive impairment or Alzheimer disease. Global neocortical β‐amyloid …
Total citations
Scholar articles
G Chételat, VL Villemagne, P Bourgeat, KE Pike… - Annals of neurology, 2010