Senolytics combat COVID-19 in aging X Zhang, M Suda, Y Zhu Nature aging 3 (7), 762-763, 2023 | | 2023 |
Local senolysis in aged mice only partially replicates the benefits of systemic senolysis JN Farr, D Saul, ML Doolittle, J Kaur, JL Rowsey, SJ Vos, MN Froemming, ... The Journal of clinical investigation 133 (8), 2023 | 26 | 2023 |
Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance X Zhang, VM Pearsall, CM Carver, EJ Atkinson, BDS Clarkson, EM Grund, ... Nature communications 13 (1), 5671, 2022 | 44 | 2022 |
Cellular senescence: a key therapeutic target in aging and diseases L Zhang, LE Pitcher, MJ Yousefzadeh, LJ Niedernhofer, PD Robbins, ... The Journal of Clinical Investigation 132 (15), 2022 | 173 | 2022 |
Selective Vulnerability of Senescent Glioblastoma Cells to BCL-XL Inhibition M Rahman, I Olson, M Mansour, LP Carlstrom, R Sutiwisesak, R Saber, ... Molecular Cancer Research 20 (6), 938-948, 2022 | 32 | 2022 |
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans Y Zhu, LGPL Prata, EOW Gerdes, JME Netto, T Pirtskhalava, N Giorgadze, ... EBioMedicine, 103912, 2022 | 39 | 2022 |
Development of a novel senolytic by precise disruption of FOXO4-p53 complex U Tripathi, S Chaib, EOW Gerdes, KA Hogan, Y Zhu EBioMedicine 74, 2021 | 4 | 2021 |
Fisetin for COVID‐19 in skilled nursing facilities: Senolytic trials in the COVID era BP Verdoorn, TK Evans, GJ Hanson, Y Zhu, LGP Langhi Prata, ... Journal of the American Geriatrics Society 69 (11), 3023-3033, 2021 | 42 | 2021 |
SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3 U Tripathi, R Nchioua, LGPL Prata, Y Zhu, EOW Gerdes, N Giorgadze, ... Aging (Albany NY) 13 (18), 21838, 2021 | 65 | 2021 |
Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders RM LABERGE, J Campisi, A DAVALOS, M DEMARIA, N David, ... | 2 | 2021 |
Epigenetic and senescence markers indicate an accelerated ageing-like state in women with preeclamptic pregnancies S Suvakov, R Ghamrawi, H Cubro, H Tu, WM White, YSB Tobah, NM Milic, ... EBioMedicine 70, 103536, 2021 | 27 | 2021 |
Treating liver disease by selectively eliminating senescent cells RM Laberge, J Campisi, M Demaria, N David, JL Kirkland, T Tchkonia, ... US Patent App. 17/114,379, 2021 | | 2021 |
Senolytics reduce coronavirus-related mortality in old mice CD Camell, MJ Yousefzadeh, Y Zhu, LGPL Prata, MA Huggins, M Pierson, ... Science, 2021 | 221 | 2021 |
An aged immune system drives senescence and ageing of solid organs MJ Yousefzadeh, RR Flores, Y Zhu, ZC Schmiechen, RW Brooks, ... Nature 594 (7861), 100-105, 2021 | 489 | 2021 |
Mechanisms of vascular dysfunction in the interleukin-10–deficient murine model of preeclampsia indicate nitric oxide dysregulation H Cubro, KA Nath, S Suvakov, O Garcia-Valencia, S Parashuram, ... Kidney international 99 (3), 646-656, 2021 | 15 | 2021 |
Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice M Ogrodnik, SA Evans, E Fielder, S Victorelli, P Kruger, H Salmonowicz, ... Aging Cell 20 (2), e13296, 2021 | 241 | 2021 |
Immune checkpoint protein VSIG4 as a biomarker of aging in murine adipose tissue BM Hall, AS Gleiberman, E Strom, PA Krasnov, D Frescas, S Vujcic, ... Aging cell 19 (10), e13219, 2020 | 23 | 2020 |
Compositions for use in the treatment of senescence-assiocated disease and disorders RM LABERGE, J Campisi, A DAVALOS, M DEMARIA, N David, ... | | 2020 |
The senescence-associated secretome as an indicator of age and medical risk MJ Schafer, X Zhang, A Kumar, EJ Atkinson, Y Zhu, S Jachim, DL Mazula, ... JCI insight 5 (12), 2020 | 224 | 2020 |
Discovery, development, and future application of senolytics: theories and predictions EO Wissler Gerdes, Y Zhu, T Tchkonia, JL Kirkland The FEBS journal 287 (12), 2418-2427, 2020 | 137 | 2020 |