Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 20:09, 10 November 2007 (UTC)
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Proteins without matches (22)
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Proteins with a High Potential Match (3)
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Manual Inspection (Page not found) (12)
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Protein Status Grid - Date: 20:09, 10 November 2007 (UTC)
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Vebose Log - Date: 20:09, 10 November 2007 (UTC)
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- INFO: Beginning work on AGRP... {November 10, 2007 11:38:46 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein AGRP image.jpg {November 10, 2007 11:39:17 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 11:39:35 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_AGRP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hyk.
| PDB = {{PDB2|1hyk}}, {{PDB2|1mr0}}
| Name = Agouti related protein homolog (mouse)
| HGNCid = 330
| Symbol = AGRP
| AltSymbols =; AGRT; ART; ASIP2; MGC118963
| OMIM = 602311
| ECnumber =
| Homologene = 7184
| MGIid = 892013
| GeneAtlas_image1 = PBB_GE_AGRP_207193_at_tn.png
| Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0005184 |text = neuropeptide hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}} {{GNF_GO|id=GO:0007631 |text = feeding behavior}} {{GNF_GO|id=GO:0009755 |text = hormone-mediated signaling}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 181
| Hs_Ensembl = ENSG00000159723
| Hs_RefseqProtein = NP_001129
| Hs_RefseqmRNA = NM_001138
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 66073978
| Hs_GenLoc_end = 66075217
| Hs_Uniprot = O00253
| Mm_EntrezGene = 11604
| Mm_Ensembl = ENSMUSG00000005705
| Mm_RefseqmRNA = NM_007427
| Mm_RefseqProtein = NP_031453
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 108455827
| Mm_GenLoc_end = 108457427
| Mm_Uniprot = Q3UU47
}}
}}
'''Agouti related protein homolog (mouse)''', also known as '''AGRP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Agouti-related protein is an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation. Agouti-related protein is alternatively spliced into 2 variants which differ in 5' untranslated sequence length.<ref>{{cite web | title = Entrez Gene: AGRP agouti related protein homolog (mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=181| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wilson BD, Ollmann MM, Barsh GS |title=The role of agouti-related protein in regulating body weight. |journal=Molecular medicine today |volume=5 |issue= 6 |pages= 250-6 |year= 1999 |pmid= 10366820 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on AKAP13... {November 10, 2007 12:00:02 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 12:00:41 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = A kinase (PRKA) anchor protein 13
| HGNCid = 371
| Symbol = AKAP13
| AltSymbols =; AKAP-Lbc; BRX; FLJ11952; FLJ43341; HA-3; Ht31; LBC; PROTO-LB; PROTO-LBC; c-lbc
| OMIM = 604686
| ECnumber =
| Homologene = 4903
| MGIid = 2676556
| Function = {{GNF_GO|id=GO:0004691 |text = cAMP-dependent protein kinase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005085 |text = guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005089 |text = Rho guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0016301 |text = kinase activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005624 |text = membrane fraction}}
| Process = {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0035023 |text = regulation of Rho protein signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 11214
| Hs_Ensembl = ENSG00000170776
| Hs_RefseqProtein = NP_006729
| Hs_RefseqmRNA = NM_006738
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 83578821
| Hs_GenLoc_end = 84093590
| Hs_Uniprot = Q12802
| Mm_EntrezGene = 75547
| Mm_Ensembl = ENSMUSG00000066406
| Mm_RefseqmRNA = XM_133543
| Mm_RefseqProtein = XP_133543
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 75329069
| Mm_GenLoc_end = 75610217
| Mm_Uniprot =
}}
}}
'''A kinase (PRKA) anchor protein 13''', also known as '''AKAP13''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in at least 3 transcript variants encoding different isoforms containing a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway and, in addition, function as protein kinase A-anchoring proteins.<ref>{{cite web | title = Entrez Gene: AKAP13 A kinase (PRKA) anchor protein 13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11214| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ATF6... {November 10, 2007 12:00:41 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 12:01:37 PM PST}
- CREATED: Created new protein page: ATF6 {November 10, 2007 12:01:44 PM PST}
- INFO: Beginning work on BCAP31... {November 10, 2007 11:54:29 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 11:55:36 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = B-cell receptor-associated protein 31
| HGNCid = 16695
| Symbol = BCAP31
| AltSymbols =; CDM; 6C6-AG; BAP31; DXS1357E
| OMIM = 300398
| ECnumber =
| Homologene = 38095
| MGIid = 1350933
| GeneAtlas_image1 = PBB_GE_BCAP31_200837_at_tn.png
| Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}}
| Component = {{GNF_GO|id=GO:0000139 |text = Golgi membrane}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0006888 |text = ER to Golgi vesicle-mediated transport}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006955 |text = immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10134
| Hs_Ensembl = ENSG00000185825
| Hs_RefseqProtein = NP_005736
| Hs_RefseqmRNA = NM_005745
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 152619148
| Hs_GenLoc_end = 152643364
| Hs_Uniprot = P51572
| Mm_EntrezGene = 27061
| Mm_Ensembl = ENSMUSG00000002015
| Mm_RefseqmRNA = NM_012060
| Mm_RefseqProtein = NP_036190
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 69938903
| Mm_GenLoc_end = 69968895
| Mm_Uniprot = Q3U9U5
}}
}}
'''B-cell receptor-associated protein 31''', also known as '''BCAP31''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CA3... {November 10, 2007 11:39:35 AM PST}
- UPLOAD: Added new Image to wiki:
{November 10, 2007 11:40:07 AM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 11:40:19 AM PST}
- CREATED: Created new protein page: CA3 {November 10, 2007 11:40:27 AM PST}
- INFO: Beginning work on CCNB2... {November 10, 2007 11:52:21 AM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 11:53:28 AM PST}
- CREATED: Created new protein page: CCNB2 {November 10, 2007 11:53:35 AM PST}
- INFO: Beginning work on CEBPD... {November 10, 2007 11:40:27 AM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 11:40:47 AM PST}
- CREATED: Created new protein page: CEBPD {November 10, 2007 11:40:56 AM PST}
- INFO: Beginning work on CHRNA3... {November 10, 2007 11:40:56 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 11:42:09 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cholinergic receptor, nicotinic, alpha 3
| HGNCid = 1957
| Symbol = CHRNA3
| AltSymbols =; MGC104879
| OMIM = 118503
| ECnumber =
| Homologene = 591
| MGIid = 87887
| GeneAtlas_image1 = PBB_GE_CHRNA3_210221_at_tn.png
| GeneAtlas_image2 = PBB_GE_CHRNA3_211587_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_CHRNA3_211772_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004889 |text = nicotinic acetylcholine-activated cation-selective channel activity}} {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005230 |text = extracellular ligand-gated ion channel activity}} {{GNF_GO|id=GO:0015464 |text = acetylcholine receptor activity}} {{GNF_GO|id=GO:0030594 |text = neurotransmitter receptor activity}}
| Component = {{GNF_GO|id=GO:0005892 |text = nicotinic acetylcholine-gated receptor-channel complex}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1136
| Hs_Ensembl = ENSG00000080644
| Hs_RefseqProtein = NP_000734
| Hs_RefseqmRNA = NM_000743
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 76672452
| Hs_GenLoc_end = 76700692
| Hs_Uniprot = P32297
| Mm_EntrezGene = 110834
| Mm_Ensembl = ENSMUSG00000032303
| Mm_RefseqmRNA = NM_145129
| Mm_RefseqProtein = NP_660111
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 54809480
| Mm_GenLoc_end = 54824696
| Mm_Uniprot = Q0VBK4
}}
}}
'''Cholinergic receptor, nicotinic, alpha 3''', also known as '''CHRNA3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CLEC4M... {November 10, 2007 11:56:39 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CLEC4M image.jpg {November 10, 2007 11:57:31 AM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 11:58:02 AM PST}
- CREATED: Created new protein page: CLEC4M {November 10, 2007 11:58:10 AM PST}
- INFO: Beginning work on CYP24A1... {November 10, 2007 11:42:09 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 11:42:59 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cytochrome P450, family 24, subfamily A, polypeptide 1
| HGNCid = 2602
| Symbol = CYP24A1
| AltSymbols =; CP24; CYP24; MGC126273; MGC126274; P450-CC24
| OMIM = 126065
| ECnumber =
| Homologene = 68094
| MGIid = 88593
| GeneAtlas_image1 = PBB_GE_CYP24A1_206504_at_tn.png
| Function = {{GNF_GO|id=GO:0004497 |text = monooxygenase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0008403 |text = 25-hydroxycholecalciferol-24-hydroxylase activity}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0030342 |text = 1-alpha,25-dihydroxyvitamin D3 (1,25-(OH)2D3) 24-hydroxylase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0042359 |text = vitamin D metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1591
| Hs_Ensembl = ENSG00000019186
| Hs_RefseqProtein = NP_000773
| Hs_RefseqmRNA = NM_000782
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 52203395
| Hs_GenLoc_end = 52223931
| Hs_Uniprot = Q07973
| Mm_EntrezGene = 13081
| Mm_Ensembl = ENSMUSG00000038567
| Mm_RefseqmRNA = NM_009996
| Mm_RefseqProtein = NP_034126
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 170174170
| Mm_GenLoc_end = 170188343
| Mm_Uniprot = Q3TP55
}}
}}
'''Cytochrome P450, family 24, subfamily A, polypeptide 1''', also known as '''CYP24A1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system.<ref>{{cite web | title = Entrez Gene: CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1591| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Okuda K, Usui E, Ohyama Y |title=Recent progress in enzymology and molecular biology of enzymes involved in vitamin D metabolism. |journal=J. Lipid Res. |volume=36 |issue= 8 |pages= 1641-52 |year= 1995 |pmid= 7595086 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on EDN3... {November 10, 2007 11:42:59 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 11:43:55 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Endothelin 3
| HGNCid = 3178
| Symbol = EDN3
| AltSymbols =; ET3; MGC15067; MGC61498
| OMIM = 131242
| ECnumber =
| Homologene = 88
| MGIid = 95285
| GeneAtlas_image1 = PBB_GE_EDN3_208399_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_EDN3_217154_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0009405 |text = pathogenesis}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}} {{GNF_GO|id=GO:0019229 |text = regulation of vasoconstriction}} {{GNF_GO|id=GO:0030318 |text = melanocyte differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1908
| Hs_Ensembl = ENSG00000124205
| Hs_RefseqProtein = NP_000105
| Hs_RefseqmRNA = NM_000114
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 57308877
| Hs_GenLoc_end = 57334442
| Hs_Uniprot = P14138
| Mm_EntrezGene = 13616
| Mm_Ensembl = ENSMUSG00000027524
| Mm_RefseqmRNA = NM_007903
| Mm_RefseqProtein = NP_031929
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 174403712
| Mm_GenLoc_end = 174426981
| Mm_Uniprot = P48299
}}
}}
'''Endothelin 3''', also known as '''EDN3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.<ref>{{cite web | title = Entrez Gene: EDN3 endothelin 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1908| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Calderone RA |title=Molecular interactions at the interface of Candida albicans and host cells. |journal=Arch. Med. Res. |volume=24 |issue= 3 |pages= 275-9 |year= 1994 |pmid= 8298278 |doi= }}
*{{cite journal | author=Hofstra RM, Osinga J, Buys CH |title=Mutations in Hirschsprung disease: when does a mutation contribute to the phenotype. |journal=Eur. J. Hum. Genet. |volume=5 |issue= 4 |pages= 180-5 |year= 1998 |pmid= 9359036 |doi= }}
*{{cite journal | author=Parisi MA, Kapur RP |title=Genetics of Hirschsprung disease. |journal=Curr. Opin. Pediatr. |volume=12 |issue= 6 |pages= 610-7 |year= 2001 |pmid= 11106284 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on EGR2... {November 10, 2007 11:43:56 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein EGR2 image.jpg {November 10, 2007 11:44:27 AM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 11:44:47 AM PST}
- CREATED: Created new protein page: EGR2 {November 10, 2007 11:44:55 AM PST}
- INFO: Beginning work on EIF2B5... {November 10, 2007 11:50:53 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 11:51:38 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
| HGNCid = 3261
| Symbol = EIF2B5
| AltSymbols =; EIF-2B; CACH; CLE; EIF2Bepsilon; LVWM
| OMIM = 603945
| ECnumber =
| Homologene = 2903
| MGIid = 2446176
| GeneAtlas_image1 = PBB_GE_EIF2B5_212351_at_tn.png
| Function = {{GNF_GO|id=GO:0003743 |text = translation initiation factor activity}} {{GNF_GO|id=GO:0005085 |text = guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008415 |text = acyltransferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005851 |text = eukaryotic translation initiation factor 2B complex}}
| Process = {{GNF_GO|id=GO:0001541 |text = ovarian follicle development}} {{GNF_GO|id=GO:0009408 |text = response to heat}} {{GNF_GO|id=GO:0009749 |text = response to glucose stimulus}} {{GNF_GO|id=GO:0014002 |text = astrocyte development}} {{GNF_GO|id=GO:0014003 |text = oligodendrocyte development}} {{GNF_GO|id=GO:0042552 |text = myelination}} {{GNF_GO|id=GO:0043434 |text = response to peptide hormone stimulus}} {{GNF_GO|id=GO:0045948 |text = positive regulation of translational initiation}} {{GNF_GO|id=GO:0051716 |text = cellular response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8893
| Hs_Ensembl = ENSG00000145191
| Hs_RefseqProtein = NP_003898
| Hs_RefseqmRNA = NM_003907
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 185335520
| Hs_GenLoc_end = 185345792
| Hs_Uniprot = Q13144
| Mm_EntrezGene = 224045
| Mm_Ensembl = ENSMUSG00000003235
| Mm_RefseqmRNA = NM_172265
| Mm_RefseqProtein = NP_758469
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 20412360
| Mm_GenLoc_end = 20422866
| Mm_Uniprot = Q8CHW4
}}
}}
'''Eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa''', also known as '''EIF2B5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Leegwater PA, Pronk JC, van der Knaap MS |title=Leukoencephalopathy with vanishing white matter: from magnetic resonance imaging pattern to five genes. |journal=J. Child Neurol. |volume=18 |issue= 9 |pages= 639-45 |year= 2003 |pmid= 14572143 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on EPHB1... {November 10, 2007 11:44:55 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein EPHB1 image.jpg {November 10, 2007 11:45:09 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 11:45:29 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_EPHB1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2djs.
| PDB = {{PDB2|2djs}}
| Name = EPH receptor B1
| HGNCid = 3392
| Symbol = EPHB1
| AltSymbols =; NET; ELK; EPHT2; FLJ37986; Hek6
| OMIM = 600600
| ECnumber =
| Homologene = 20936
| MGIid = 1096337
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005003 |text = ephrin receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}} {{GNF_GO|id=GO:0007399 |text = nervous system development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2047
| Hs_Ensembl =
| Hs_RefseqProtein = NP_004432
| Hs_RefseqmRNA = NM_004441
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 270190
| Mm_Ensembl = ENSMUSG00000032537
| Mm_RefseqmRNA = NM_173447
| Mm_RefseqProtein = NP_775623
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 101779749
| Mm_GenLoc_end = 102079716
| Mm_Uniprot = Q8CA63
}}
}}
'''EPH receptor B1''', also known as '''EPHB1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.<ref>{{cite web | title = Entrez Gene: EPHB1 EPH receptor B1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2047| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Flanagan JG, Vanderhaeghen P |title=The ephrins and Eph receptors in neural development. |journal=Annu. Rev. Neurosci. |volume=21 |issue= |pages= 309-45 |year= 1998 |pmid= 9530499 |doi= 10.1146/annurev.neuro.21.1.309 }}
*{{cite journal | author=Zhou R |title=The Eph family receptors and ligands. |journal=Pharmacol. Ther. |volume=77 |issue= 3 |pages= 151-81 |year= 1998 |pmid= 9576626 |doi= }}
*{{cite journal | author=Abrahamson DR, Robert B, Hyink DP, ''et al.'' |title=Origins and formation of microvasculature in the developing kidney. |journal=Kidney Int. Suppl. |volume=67 |issue= |pages= S7-11 |year= 1998 |pmid= 9736245 |doi= }}
*{{cite journal | author=Holder N, Klein R |title=Eph receptors and ephrins: effectors of morphogenesis. |journal=Development |volume=126 |issue= 10 |pages= 2033-44 |year= 1999 |pmid= 10207129 |doi= }}
*{{cite journal | author=Wilkinson DG |title=Eph receptors and ephrins: regulators of guidance and assembly. |journal=Int. Rev. Cytol. |volume=196 |issue= |pages= 177-244 |year= 2000 |pmid= 10730216 |doi= }}
*{{cite journal | author=Xu Q, Mellitzer G, Wilkinson DG |title=Roles of Eph receptors and ephrins in segmental patterning. |journal=Philos. Trans. R. Soc. Lond., B, Biol. Sci. |volume=355 |issue= 1399 |pages= 993-1002 |year= 2001 |pmid= 11128993 |doi= 10.1098/rstb.2000.0635 }}
*{{cite journal | author=Wilkinson DG |title=Multiple roles of EPH receptors and ephrins in neural development. |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 155-64 |year= 2001 |pmid= 11256076 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on F2RL2... {November 10, 2007 11:46:23 AM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 11:47:05 AM PST}
- CREATED: Created new protein page: F2RL2 {November 10, 2007 11:47:12 AM PST}
- INFO: Beginning work on FBL... {November 10, 2007 11:45:29 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein FBL image.jpg {November 10, 2007 11:46:07 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 11:46:23 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FBL_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ipx.
| PDB = {{PDB2|2ipx}}
| Name = Fibrillarin
| HGNCid = 3599
| Symbol = FBL
| AltSymbols =; FIB; FLRN; RNU3IP1
| OMIM = 134795
| ECnumber =
| Homologene = 1099
| MGIid = 95486
| GeneAtlas_image1 = PBB_GE_FBL_211623_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0008168 |text = methyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0030529 |text = ribonucleoprotein complex}}
| Process = {{GNF_GO|id=GO:0006364 |text = rRNA processing}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2091
| Hs_Ensembl = ENSG00000105202
| Hs_RefseqProtein = NP_001427
| Hs_RefseqmRNA = NM_001436
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 45016938
| Hs_GenLoc_end = 45028848
| Hs_Uniprot = P22087
| Mm_EntrezGene = 14113
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_007991
| Mm_RefseqProtein = NP_032017
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Fibrillarin''', also known as '''FBL''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin.<ref>{{cite web | title = Entrez Gene: FBL fibrillarin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2091| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on METAP2... {November 10, 2007 11:58:44 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein METAP2 image.jpg {November 10, 2007 11:59:41 AM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 11:59:54 AM PST}
- CREATED: Created new protein page: METAP2 {November 10, 2007 12:00:02 PM PST}
- INFO: Beginning work on NUP153... {November 10, 2007 11:53:35 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein NUP153 image.jpg {November 10, 2007 11:54:10 AM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 11:54:22 AM PST}
- CREATED: Created new protein page: NUP153 {November 10, 2007 11:54:29 AM PST}
- INFO: Beginning work on PTGES3... {November 10, 2007 11:58:10 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PTGES3 image.jpg {November 10, 2007 11:58:24 AM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 11:58:36 AM PST}
- CREATED: Created new protein page: PTGES3 {November 10, 2007 11:58:44 AM PST}
- INFO: Beginning work on SERPINA7... {November 10, 2007 11:48:25 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein SERPINA7 image.jpg {November 10, 2007 11:48:58 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 11:49:12 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SERPINA7_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ceo.
| PDB = {{PDB2|2ceo}}
| Name = Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
| HGNCid = 11583
| Symbol = SERPINA7
| AltSymbols =; TBG
| OMIM = 314200
| ECnumber =
| Homologene = 20113
| MGIid = 3041197
| GeneAtlas_image1 = PBB_GE_SERPINA7_206386_at_tn.png
| Function = {{GNF_GO|id=GO:0004867 |text = serine-type endopeptidase inhibitor activity}} {{GNF_GO|id=GO:0005488 |text = binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6906
| Hs_Ensembl = ENSG00000123561
| Hs_RefseqProtein = NP_000345
| Hs_RefseqmRNA = NM_000354
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 105163853
| Hs_GenLoc_end = 105169385
| Hs_Uniprot = P05543
| Mm_EntrezGene = 331535
| Mm_Ensembl = ENSMUSG00000031271
| Mm_RefseqmRNA = NM_177920
| Mm_RefseqProtein = NP_808588
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 134426145
| Mm_GenLoc_end = 134431581
| Mm_Uniprot = Q3UEL9
}}
}}
'''Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7''', also known as '''SERPINA7''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SYT1... {November 10, 2007 11:47:12 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein SYT1 image.jpg {November 10, 2007 11:48:02 AM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 11:48:17 AM PST}
- CREATED: Created new protein page: SYT1 {November 10, 2007 11:48:25 AM PST}
- INFO: Beginning work on TNFRSF4... {November 10, 2007 11:50:01 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TNFRSF4 image.jpg {November 10, 2007 11:50:36 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 11:50:53 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TNFRSF4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2hev.
| PDB = {{PDB2|2hev}}, {{PDB2|2hey}}
| Name = Tumor necrosis factor receptor superfamily, member 4
| HGNCid = 11918
| Symbol = TNFRSF4
| AltSymbols =; ACT35; CD134; OX40; TXGP1L
| OMIM = 600315
| ECnumber =
| Homologene = 2496
| MGIid = 104512
| GeneAtlas_image1 = PBB_GE_TNFRSF4_214228_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005031 |text = tumor necrosis factor receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7293
| Hs_Ensembl = ENSG00000186827
| Hs_RefseqProtein = NP_003318
| Hs_RefseqmRNA = NM_003327
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 1136569
| Hs_GenLoc_end = 1139375
| Hs_Uniprot = P43489
| Mm_EntrezGene = 22163
| Mm_Ensembl = ENSMUSG00000029075
| Mm_RefseqmRNA = NM_011659
| Mm_RefseqProtein = NP_035789
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 154857495
| Mm_GenLoc_end = 154860412
| Mm_Uniprot = P47741
}}
}}
'''Tumor necrosis factor receptor superfamily, member 4''', also known as '''TNFRSF4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.<ref>{{cite web | title = Entrez Gene: TNFRSF4 tumor necrosis factor receptor superfamily, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7293| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Weinberg AD |title=OX40: targeted immunotherapy--implications for tempering autoimmunity and enhancing vaccines. |journal=Trends Immunol. |volume=23 |issue= 2 |pages= 102-9 |year= 2002 |pmid= 11929124 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TSPY1... {November 10, 2007 11:49:12 AM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 11:49:53 AM PST}
- CREATED: Created new protein page: TSPY1 {November 10, 2007 11:50:01 AM PST}
- INFO: Beginning work on WASF1... {November 10, 2007 11:51:38 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 11:52:21 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = WAS protein family, member 1
| HGNCid = 12732
| Symbol = WASF1
| AltSymbols =; FLJ31482; KIAA0269; SCAR1; WAVE; WAVE1
| OMIM = 605035
| ECnumber =
| Homologene = 2920
| MGIid = 1890563
| GeneAtlas_image1 = PBB_GE_WASF1_204165_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005741 |text = mitochondrial outer membrane}} {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}} {{GNF_GO|id=GO:0030027 |text = lamellipodium}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0030041 |text = actin filament polymerization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8936
| Hs_Ensembl = ENSG00000112290
| Hs_RefseqProtein = NP_001020105
| Hs_RefseqmRNA = NM_001024934
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 110528382
| Hs_GenLoc_end = 110607819
| Hs_Uniprot = Q92558
| Mm_EntrezGene = 83767
| Mm_Ensembl = ENSMUSG00000019831
| Mm_RefseqmRNA = NM_031877
| Mm_RefseqProtein = NP_114083
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 40571988
| Mm_GenLoc_end = 40626982
| Mm_Uniprot = Q8R5H6
}}
}}
'''WAS protein family, member 1''', also known as '''WASF1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.<ref>{{cite web | title = Entrez Gene: WASF1 WAS protein family, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8936| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on WASF2... {November 10, 2007 11:55:36 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein WASF2 image.jpg {November 10, 2007 11:56:16 AM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 11:56:32 AM PST}
- CREATED: Created new protein page: WASF2 {November 10, 2007 11:56:39 AM PST}
end log.