The study aims to assess the neurodegenerative effects of stress in the brains of Wistar rats and investigate the neuroprotective potential of Nigella sativa. Rats will be divided into control, stress-induced, Nigella sativa-treated, and stress-induced with Nigella sativa treatment groups. Stress is hypothesized to negatively impact brain regions like the frontal cortex, hippocampus, and amygdala. The study will evaluate behavioral changes, neurotransmitter levels, histopathological changes in the brain, and effects of Nigella sativa administration. Results could provide evidence for using Nigella sativa as a neuroprotectant against stress-induced brain damage.