Expert Event Legal challenges and opportunities for digital health innovationDayOne
Introduction by Thomas Brenzikofer, DayOne, Basel Area Business & Innovation
Greenfield or jungle? Navigating the legal landscape for digital healthcare innovation
At first sight, it’s hard not to agree that dealing with the legal aspects of creating healthcare innovation is — although necessary — a rather unsexy topic. So it comes as no surprise that the DayOne Experts Event “Legal challenges and opportunities for healthcare innovation”, held online on September 30, attracted a slightly smaller audience than when the talks usually concern revolutionary new pieces of digital technology ready to disrupt healthcare as we know it — for the better.
Future of aging day one 20200630 zaynakhayatDayOne
This document discusses the future of aging and outlines several shifts that are expected to occur. It summarizes a book on the topic that explores how aging is transforming in areas like identity, community, health interventions, and technology. The document presents examples of emerging trends like reframing what it means to age, new models for aging communities, a shift from treating illness to empowering health, and technologies that can enhance independence and quality of life for older adults.
Value-based Healthcare - Towards a systems approach in chronic diseasesnDayOne
Role of patient journey in science, predictive modeling and high-risk patients in early stages of disease progression, in real world context. Presented by Michael Rebhan, Novartis at the DayOne Basel event in June 2020
Value-based Healthcare today and tomorrow by Deloitte.DayOne
VBHC today and tomorrow
There is an increasing need for a value-based healthcare model based on holistic patient and health system outcomes, which can only be achieved through genuine collaboration between stakeholders. Value-based contracts require defining appropriate outcome measures, collecting and analyzing real-world data, and addressing challenges such as misaligned incentives among payers, providers, and pharmaceutical companies. The COVID-19 pandemic is likely to accelerate trends in healthcare such as greater emphasis on value-based care, data analytics, technology innovation, and patient engagement. Post-COVID, there are opportunities for life sciences companies to strengthen evidence of value, support health system capacity and digital adoption, and engage differently with regulators and payers.
This document discusses value-based healthcare and consists of presentations from a DayOne Experts event on June 18, 2020. It explores why value-based healthcare is needed, how it is implemented, and who benefits from it. The event included breakout sessions on how COVID-19 could catalyze value-based approaches, how it may change disease treatment and research, its potential to trigger innovation and new business models, and how to define and measure healthcare value from the patient perspective.
The Aging Well Catalyst Project would involve a series of 5 workshops bringing together stakeholders from areas like healthcare, technology, and senior care to identify innovation opportunities for an aging society. The outputs would be published in a series of white papers and culminate in a public event. The Aging Well Accelerator would select and accelerate the top 3 startups in technologies supporting healthy aging over 6 months to help their path to market. Both projects aim to drive innovation and collaboration around aging well.
How can digital bridge the mental health gaps?
Mental health is a story of gaps. This was made clear by all the speakers and panelists at DayOne’s most recent Expert Meeting titled “Measuring the Unmeasurable - will digital pave the way for new treatments in mental health?” which took place in Basel. Check out the slides from the event here.
20191203 DOE Data Driven Healthcare- Expert EventDayOne
This document summarizes a presentation on data-driven healthcare given at the DayOne Experts conference in Basel on December 3rd, 2019. The presentation discusses whether the healthcare system is ready for data-driven approaches and what is needed to enable new data-driven health solutions. It notes that while digitalization in Swiss medical practices is increasing, coordination between different parts of the treatment chain remains a challenge. The Swiss Personalized Health Network aims to connect different health data sources and establish national infrastructure to enable interoperable exchange of health data for research purposes. University hospitals are working to structure, standardize and integrate different types of clinical and research data according to SPHN requirements.
Healthcare delivery in the periphery workshop outputDayOne
This document summarizes a tri-national workshop on healthcare delivery in peripheral regions. The workshop brought together participants from Germany, France, and Switzerland to identify challenges in peripheral healthcare, develop collaborative projects to address these challenges, and plan next steps. Three priority projects were selected: 1) A platform for hospitals to share best practices and develop an adherence app, 2) A workshop on technological solutions to attract physicians to peripheral areas, and 3) An exchange program for nurses and nursing students to collaborate with technology companies and work towards harmonizing training across borders. Immediate next steps included reporting outcomes to relevant conferences and planning an expert workshop in early 2020.
What does “patient centricity” really mean and how is it actually done? This was the driving question of the DayOne Experts Meeting in Basel, co-hosted by Arcondis.
YouROK delivers a positive emotional health platform to help kids, families and professionals prevent mental health issues and build healthier families. The platform includes an app that builds emotional resilience while measuring deterioration in emotional well-being to proactively offer targeted treatment. Using deep learning to assess emotional health, YouROK keeps parents and professionals informed of a child's mental health status through a dashboard and alerts.
This document provides information about Shanghai, China including its population, transportation infrastructure, universities, and healthcare system. It discusses several major hospitals in Shanghai - Renji Hospital, Zhongshan Hospital, and Fudan Cancer Institute. It provides details on the capacity, staffing, and services of each hospital. The document raises questions about ethics, data, privacy, and how to optimize hospitals in China given challenges with lack of universal healthcare, doctor shortages, and hospital overcrowding.
Durrenmatt's Computer Scientists: Caught between moral and technological deve...DayOne
Input speech to panel on ethics from Bram Stieltjes, University Hospital Basel at the DayOne Conference 2019 Shaping the future of Health September 9th 2019
How start-up funding in digital health can workDayOne
The document outlines different stages of start-up funding for digital health companies, including idea stage with the founder's own money, co-founder stage with two owners, family and friends investing, seed rounds with business angels, Series A rounds with venture capitalists, and successful IPOs. It notes that most start-ups fail due to running out of money and not engaging with potential investors, experts, regulators, payers, users, and patients who could help. The presentation encourages understanding these stakeholders and what can be done to succeed in obtaining funding.
Input speech to panel on future financing by Julien Salaberry from Galen Growth Asia at introduce the DayOne Conference 2019 Shaping the future of Health September 9th 2019
The DayOne Conference 2019 was held on September 9th at FHNW in Muttenz. The one-day conference focused on shaping the future of health and included panels with patients and industry professionals, sessions on ethics, financing innovation, and a workshop. There were over 450 participants, including 30 projects/entrepreneurs, 40 volunteers, and a keynote from digital health futurist Maneesh Juneja. The conference was organized by the DayOne team and supported various partners to bring together over 1500 healthcare innovators in the Basel area.
The document discusses shaping the future of health care and how AI could be used to improve patient care and staff experience. It describes how AI technologies like neural networks are being developed to analyze CCTV footage to predict medical emergencies and alerts first responders. However, care must be taken to avoid discrimination and harm when using these automated models. The document also questions how AI can be used to create a better world and return on investment for health systems.
Day one conference projects with journey mapsDayOne
DayOne Conference 2019 projects and journey maps. 30 ventures presented their solutions and together with conference participants built a journey map of their future.
POTENTIAL TARGET DISEASES FOR GENE THERAPY SOURAV.pptxsouravpaul769171
Theoretically, gene therapy is the permanent solution for genetic diseases. But it has several complexities. At its current stage, it is not accessible to most people due to its huge cost. A breakthrough may come anytime and a day may come when almost every disease will have a gene therapy Gene therapy have the potential to revolutionize the practice of medicine.
Causes Of Tooth Loss
PERIODONTAL PROBLEMS ( PERIODONTITIS, GINIGIVITIS)
Systemic Causes Of Tooth Loss
1. Diabetes Mellitus
2. Female Sexual Hormones Condition
3. Hyperpituitarism
4. Hyperthyroidism
5. Primary Hyperparathyroidism
6. Osteoporosis
7. Hypophosphatasia
8. Hypophosphatemia
Causes Of Tooth Loss
CARIES/ TOOTH DECAY
Causes Of Tooth Loss
CAUSES OF TOOTH LOSS
Consequence of tooth loss
Anatomic
Loss of ridge volume both height and width
Bone loss :
mandible > maxilla
Posteriorly > anteriorly
Anatomic consequences
Broader mandibular arch with constricting maxilary arch
Attached gingiva is replaced with less keratinised oral mucosa which is more readily traumatized.
Anatomic consequences
Tipping of the adjacent teeth
Supraeruption of the teeth
Traumatic occlusion
Premature occlusal contact
Anatomic Consequences
Anatomic Consequences
Physiologic consequences
Physiologic Consequences
Decreased lip support
Decreased lower facial height
Physiologic Consequences
Physiologic consequences
Education of Patient
Diagnosis, Treatment Planning, Design, Treatment, Sequencing, and Mouth Preparation
Support for Distal Extension Denture Bases
Establishment and Verification of Occlusal Relations and Tooth Arrangements
Initial Placement Procedures
Periodic Recall
Education of Patient
Informing a patient about a health matter to
secure informed consent.
Patient education should begin at the initial
contact with the patient and should continue throughout treatment.
The dentist and the patient share responsibility for the ultimate success of a removable partial denture.
This educational procedure is especially important when the treatment plan and prognosis are discussed with the patient.
Diagnosis, Treatment Planning, Design, Treatment, Sequencing, and Mouth Preparation
Begin with thorough medical and dental histories.
The complete oral examination must include both clinical and radiographic interpretation of:
caries
the condition of existing restorations
periodontal conditions
responses of teeth (especially abutment teeth) and residual ridges to previous stress
The vitality of remaining teeth
Continued…..
Occlusal plan evaluation
Arch form
Evaluation of Occlusal relationship through mounting the diagnostic cast
The dental cast surveyor is an absolute necessity in which patients are being treated with removable partial dentures.
Mouth preparations, in the appropriate sequence, should be oriented toward the goal of
providing adequate support, stability,
retention, and
a harmonious occlusion for the partial denture.
Support for Distal Extension Denture Bases
A base made to fit the anatomic ridge form does not provide adequate support under occlusal loading.
The base may be made to fit the form of the ridge when under function.
Support for Distal Extension Denture Bases
This provides support
Why Does Seminal Vesiculitis Causes Jelly-like Sperm.pptxAmandaChou9
Seminal vesiculitis can cause jelly-like sperm. Fortunately, herbal medicine Diuretic and Anti-inflammatory Pill can eliminate symptoms and cure the disease.
Mainstreaming #CleanLanguage in healthcare.pptxJudy Rees
In healthcare, every day, millions of conversations fail. They fail to cover what’s really important, fail to resolve key issues, miss the point and lead to misunderstandings and disagreements.
Clean Language is one approach that can improve things. It’s a set of precise questions – and a way of asking them – which help us all get clear on what matters, what we’d like to have happen, and what’s needed.
Around 1000 people working in healthcare have trained in Clean Language skills over the past 20+ years. People are using what they’ve learnt, in their own spheres, and share anecdotes of significant successes. But the various local initiatives have not scaled, nor connected with each other, and learning has not been widely shared.
This project, which emerged from work done by the NHS England South-West End-Of-Life Network, with help from the Q Community and especially Hesham Abdalla, aims to fix that.
EXPERIMENTAL STUDY DESIGN- RANDOMIZED CONTROLLED TRIALRishank Shahi
Randomized controlled clinical trial is a prospective experimental study.
It essentially involves comparing the outcomes in two groups of patients treated with a test treatment and a control treatment, both groups are followed over the same period of time. Prepare a plan of study or protocol
a. Define clear objectives
b. State the inclusion and exclusion criteria of case
c. Determine the sample size, place and period of study
d. Design of trial (single blind, double blind and triple blind method)
2. Define study population: Most often the patients are chosen from hospital or from the community. For example, for a study for comparison of home and sanatorium treatment, open cases of tuberculosis may be chosen.
3. Selection of participants by defined criteria as per plan:
Selection of participants should be done with precision and should be precisely stated in writing so that it can be replicated by others. For example, out of open cases of tuberculosis those who fulfill criteria for inclusion may be selected (age groups, severity of disease and treatment taken or not, etc.)
Randomization ensures that participants have an equal chance to be assigned to one of two or more groups:
One group gets the most widely accepted treatment (standard treatment/ gold standard)
The other gets the new treatment being tested, which researchers hope and have reason to believe will be better than the standard treatment
Subject variation: First, there may be bias on the part of the participants, who may subjectively feel better or report improvement if they knew they were receiving a new form of treatment.
Observer bias: The investigator measuring the outcome of a therapeutic trial may be influenced if he knows beforehand the particular procedure or therapy to which the patient has been subjected.
Evaluation bias: There may be bias in evaluation - that is, the investigator(Analyzer) may subconsciously give a favorable report of the outcome of the trial.
Co-intervention:
participants use other therapy or change behavior
Study staff, medical providers, family or friends treat participants differently.
Biased outcome ascertainment:
participants may report symptoms or outcomes differently or physicians
Investigators may elicit symptoms or outcomes differently
A technique used to prevent selection bias by concealing the allocation sequence from those assigning participants to intervention groups, until the moment of assignment.
Allocation concealment prevents researchers from influencing which participants are assigned to a given intervention group.
All clinical trials must be approved by Institutional Ethics Committee before initiation
It is mandatory to register clinical trials with Clinical Trials Registry of India
Informed consent from all study participants is mandatory.
A preclinical trial is a stage of research that begins before clinical trials, and during which important feasibility and drug safety data are collected.
Following points high.
Exploring Alternatives- Why Laparoscopy Isn't Always Best for Hydrosalpinx.pptxFFragrant
Not all women with hydrosalpinx should choose laparoscopy. Natural medicine Fuyan Pill can also be a nice option for patients, especially when they have fertility needs.
A comparative study on uroculturome antimicrobial susceptibility in apparentl...Bhoj Raj Singh
The uroculturome indicates the profile of culturable microbes inhabiting the urinary tract, and it is often required to do a urine culture to find an effective antimicrobial to treat UTIs. This study targeted to understand the profile of culturable pathogens in the urine of apparently healthy (128) and humans with clinical UTIs (161). In urine samples from UTI cases, microbial counts were 1.2×104 ± 6.02×103 colony-forming units (cfu)/ mL, while in urine samples from apparently healthy humans, the average count was 3.33± 1.34×103 cfu/ mL. In eight samples (six from UTI cases and two from apparently healthy people) of urine, Candida (C. albicans 3, C. catenulata 1, C. krusei 1, C. tropicalis 1, C. parapsiplosis 1, C. gulliermondii 1) and Rhizopus species (1) were detected. Candida krusei was detected only in a single urine sample from a healthy person and C. albicans was detected both in urine of healthy and clinical UTI cases. Fungal strains were always detected with one or more types of bacteria. Gram-positive bacteria were more commonly (OR, 1.98; CI99, 1.01-3.87) detected in urine samples of apparently healthy humans, and Gram -ve bacteria (OR, 2.74; CI99, 1.44-5.23) in urines of UTI cases. From urine samples of 161 UTI cases, a total of 90 different types of microbes were detected and, 73 samples had only a single type of bacteria. In contrast, 49, 29, 3, 4, 1, and 2 samples had 2, 3, 4, 5, 6 and 7 types of bacteria, respectively. The most common bacteria detected in urine of UTI cases was Escherichia coli detected in 52 samples, in 20 cases as the single type of bacteria, other 34 types of bacteria were detected in pure form in 53 cases. From 128 urine samples of apparently healthy people, 88 types of microbes were detected either singly or in association with others, from 64 urine samples only a single type of bacteria was detected while 34, 13, 3, 11, 2 and 1 samples yielded 2, 3, 4, 5, 6 and seven types of microbes, respectively. In the urine of apparently healthy humans too, E. coli was the most common bacteria, detected in pure culture from 10 samples followed by Staphylococcus haemolyticus (9), S. intermedius (5), and S. aureus (5), and similar types of bacteria also dominated in cases of mixed occurrence, E. coli was detected in 26, S. aureus in 22 and S. haemolyticus in 19 urine samples, respectively. Gram +ve bacteria isolated from urine samples' irrespective of health status were more often (p, <0.01) resistant than Gram -ve bacteria to ajowan oil, holy basil oil, cinnamaldehyde, and cinnamon oil, but more susceptible to sandalwood oil (p, <0.01). However, for antibiotics, Gram +ve were more often susceptible than Gram -ve bacteria to cephalosporins, doxycycline, and nitrofurantoin. The study concludes that to understand the role of good and bad bacteria in the urinary tract microbiome more targeted studies are needed to discern the isolates at the pathotype level.