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1989, PubMed
During the development of a homogeneous immunoassay for the antibiotic vancomycin, we observed in certain patient samples a quantitation difference between the enzyme multiplied immunoassay technique (EMIT) method and the comparison method, fluorescence polarization immunoassay (FPIA). This prompted us to evaluate the integrity of vancomycin in samples from renally impaired patients. Since it has been reported in the scientific literature that vancomycin degrades into an antibiotically inactive crystalline degradation product (CDP-1) in vitro, we developed high-performance liquid chromatography (HPLC) and liquid chromatography/mass spectrometry (LC/MS) methods to determine whether CDP-1 is present in patient sera. HPLC and LC/MS analysis on samples from renally impaired patients positively identified CDP-1 in fresh samples. Next, we tested the cross-reactivity of three currently available vancomycin immunoassays, radioimmunoassay (RIA) FPIA, and EMIT, to CDP-1 prepared in our laboratory. Our data suggest that CDP-1 is recognized by FPIA and RIA, both polyclonal antibody-based methods, but not by EMIT, which uses a monoclonal antibody.
Science (New York, N.Y.)
Ancient Maya astronomical tables from Xultun, Guatemala2012 •
Maya astronomical tables are recognized in bark-paper books from the Late Postclassic period (1300 to 1521 C.E.), but Classic period (200 to 900 C.E.) precursors have not been found. In 2011, a small painted room was excavated at the extensive ancient Maya ruins of Xultun, Guatemala, dating to the early 9th century C.E. The walls and ceiling of the room are painted with several human figures. Two walls also display a large number of delicate black, red, and incised hieroglyphs. Many of these hieroglyphs are calendrical in nature and relate astronomical computations, including at least two tables concerning the movement of the Moon, and perhaps Mars and Venus. These apparently represent early astronomical tables and may shed light on the later books.
"Bez Porównania"
Ingerencja boska w powieściach Williama Carletona i Władysława Orkana o epidemiach głodu2022 •
Powieści opowiadające o katastrofach ekologicznych nie mogą uniknąć jednoczesnego obnażania chorób systemów politycznych. Pomór Władysława Orkana i The Black Prophet. A Tale of the Irish Famine Williama Carletona na dwa różne sposoby mówią o klęskach głodu, które miały miejsce w połowie XIX wieku, i powiązanych z nimi patologiach społecznych. Ponure obrazy prezentowane w przywołanych narracjach dotyczą przede wszystkim tego, co Cormac Ó Gráda nazywa "zwykłą głodową mieszanką": "najpierw głodowanie, później dyzenteria i powracająca gorączka, wreszcie tyfus" 1. We wspomnianych tekstach nie da się oddzielić problemów związanych z głodem od tych wynikających z chorób systemu społecznego.
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HE ON-GOING BATTLE FOR THE SOUL OF THE ARMY
THE ON-GOING BATTLE FOR THE SOUL OF THE ARMYIt's your war too
Vojnosanitetski pregled
A novel framework for fluid/structure interaction in rapid subject specific simulations of blood flow in coronary artery bifurcations2014 •
Background/Aim. Practical difficulties, particularly long model development time, have limited the types and applicability of computational fluid dynamics simulations in numerical modeling of blood flow in serial manner. In these simulations, the most revealing flow parameters are the endothelial shear stress distribution and oscillatory shear index. The aim of this study was analyze their role in the diagnosis of the occurrence and prognosis of plaque development in coronary artery bifurcations. Methods. We developed a novel modeling technique for rapid cardiovascular hemodynamic simulations taking into account interactions between fluid domain (blood) and solid domain (artery wall). Two numerical models that represent the observed subdomains of an arbitrary patient-specific coronary artery bifurcation were created using multi-slice computed tomography (MSCT) coronagraphy and ultrasound measurements of blood velocity. Coronary flow using an in-house finite element solver PAK-FS was...
1992 •
Résumé/Abstract Cette communication présente 3 thèmes: Les méthodes d'analyse pluridisciplinaires utilisées pour faire le diagnostic du fonctionnement des réseaux commerciaux; les résultats issus de la comparaison du fonctionnement des Traditional ...
Revue Du Rhumatisme Monographies
Canal lombaire rétréci du sujet âgé : les éléments de la décision thérapeutique2011 •
Neuropsychologia
Person perception involves functional integration between the extrastriate body area and temporal pole2017 •
The majority of human neuroscience research has focussed on understanding functional organisation within segregated patches of cortex. The ventral visual stream has been associated with the detection of physical features such as faces and body parts, whereas the theory-of-mind network has been associated with making inferences about mental states and underlying character, such as whether someone is friendly, selfish, or generous. To date, however, it is largely unknown how such distinct processing components integrate neural signals. Using functional magnetic resonance imaging and connectivity analyses, we investigated the contribution of functional integration to social perception. During scanning, participants observed bodies that had previously been associated with trait-based or neutral information. Additionally, we independently localised the body perception and theory-of-mind networks. We demonstrate that when observing someone who cues the recall of stored social knowledge co...
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La Revue de Médecine Interne
Microangiopathie thrombotique et glomérulonéphrite post-infectieuse aiguë : à propos de trois cas2016 •