The incidence of stroke and dementia are diverging across the world, rising for those in low-
and middle-income countries and falling in those in high-income countries. This suggests …

Subclinical cerebrovascular disease is frequently identified in neuroimaging studies and is
thought to play a role in the pathogenesis of cognitive disorders. Identifying the etiologies of …

Background The immediate and longer-term effects of hemodialysis on cerebral circulation,
cerebral structure, and cognitive function are poorly understood. Methods In a prospective …

The pathophysiological mechanism of white matter hyperintensities of cerebral small vessel
disease (CSVD) includes an impaired blood-brain barrier (BBB) with increased permeability …

Background and Purpose—Cerebral small vessel disease (SVD) is a major cause of stroke
and dementia, but underlying disease mechanisms are still largely unknown, partly because …

Background Central arterial stiffening and increased pulsatility, with consequent cerebral
hypoperfusion, may result in structural brain damage and cognitive impairment. Methods …

Importance The rationale for intravenous thrombolysis in patients with lacunar infarcts is
debated, since it is hypothesized that the microvascular occlusion underlying lacunar …

Research has suggested that the retinal vasculature may act as a surrogate marker for
diseased cerebral vessels. Retinal vascular parameters were measured using Vessel …

Cerebral small vessel disease (CSVD) refers to a spectrum of clinical and imaging findings
resulting from pathological processes of various etiologies affecting cerebral arterioles …

Background and Purpose—Cerebral amyloid angiopathy (CAA) is a common small vessel
disease that independently effects cognition in older individuals. The pathophysiology of …