Auteurs
Astrid M Hooghiemstra, Anna E Leeuwis, Anne Suzannne Bertens, Geert Jan Biessels, Michiel L Bots, Hans-Peter Brunner-La Rocca, Jacoba P Greving, L Jaap Kappelle, Robert J van Oostenbrugge, Albert C van Rossum, Heart-Brain Connection Consortium, Wiesje M van der Flier
Publicatiedatum
2019/12
Tijdschrift
Stroke
Volume
50
Editie
12
Pagina's
3369-3375
Uitgever
Lippincott Williams & Wilkins
Beschrijving
Background and Purpose
Patients with cardiovascular disease are at increased risk for cognitive decline. We studied the occurrence and profile of cognitive impairment in 3 patient groups as exemplar conditions of hemodynamic disturbances at different levels of the heart-brain axis, including patients with heart failure (HF), carotid occlusive disease (COD), and patients with cognitive complaints and vascular brain injury on magnetic resonance imaging (possible vascular cognitive impairment [VCI]).
Methods
In 555 participants (160 HF, 107 COD, 160 possible VCI, 128 reference participants; 68±9 years; 36% F; Mini-Mental State Examination 28±2), we assessed cognitive functioning with a comprehensive test battery. Test scores were transformed into z-scores. Compound z-scores were constructed for: memory, language, attention/psychomotor speed, executive functioning, and global cognitive functioning. We …
Scholar-artikelen
AM Hooghiemstra, AE Leeuwis, AS Bertens… - Stroke, 2019