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Neurodegenerative diseases (NDDs) encompass a range of conditions that involve
progressive deterioration and dysfunction of the nervous system. Some of the
common NDDs include Alzheimer's disease (AD), Parkinson's disease (PD) …

Physical exercise is of great significance for maintaining human health. Exercise can
provide varying degrees of benefits to cognitive function at all stages of life cycle.
Currently, with the aging of the world's population and increase of life expectancy …

As one of most common and severe mental disorders, major depressive disorder
(MDD) significantly increases the risks of premature death and other medical
conditions for patients. Neuroinflammation is the abnormal immune response in the …

Mesenchymal stem cells (MSCs) have shown promise for the therapy of cerebral
ischemia in animal studies and clinical trials, yet their clinical application still faces
many challenges. Utilizing small extracellular vesicles (sEVs) may overcome these …

The production of plastic is still increasing globally, which has led to an increasing
number of plastic particles in the environment. Nanoplastics (NPs) can penetrate the
blood-brain barrier and induce neurotoxicity, but in-depth mechanism and effective …

Background Vascular dementia (VD) is the second most common type of dementia
after Alzheimer's disease. β-asarone, a major component of Acorus tatarinowii
Schott, is important in neurodegenerative and neurovascular diseases. Studies have …

Presenilin, a transmembrane protein primarily known for its role in Alzheimer's
disease (AD) as part of the γ-secretase complex, has garnered increased attention
due to its multifaceted functions in various cellular processes. Recent investigations …

Background Depression is a severe mental illness that endangers human health.
Depressed individuals are prone to sleep less and to the loss of appetite for food;
their thinking and cognition processes, as well as mood, may even be affected …

Neurotrophins (NTs) as nerve growth factor (NGF) and brain-derived neurotrophic
factor (BDNF) play multiple roles in different settings including neuronal
development, function and survival in both the peripheral and the central nervous …

Background Depression is one of the most common psychological disorders among
multiple sclerosis (MS) patients that characterized as the first symptoms. Ellagic acid
is a natural polyphenol that may have neuroprotective properties through antioxidant …