The rapid folding of certain proteins can be described theoretically using an energy
landscape in the shape of a folding funnel. New techniques have allowed the examination of …

Proteins are highly complex molecules with features exquisitely selected by nature to carry
out essential biological functions. Physical chemistry and polymer physics provide us with …

What is the shape of the conformational free energy landscape for the collapse of a single
homopolymer molecule? We model the dynamics of homopolymer collapse in a poor …

A systematic investigation of the solvent's dynamic influence on activated barrier crossings
on an electronic ground state is performed using ultrafast two-dimensional infrared chemical …

The highly charged RNA molecules, with each phosphate carrying a single negative charge,
cannot fold into well-defined architectures with tertiary interactions in the absence of ions …

Intrinsically disordered proteins do not adopt well-defined structures, yet they still play
functional roles in many different aspects of biology. Their lack of stable conformations …

Single-molecule experiments in which proteins are unfolded by applying mechanical
stretching forces generally force unfolding to proceed along a reaction coordinate that is …

A long time ago, Kuhn predicted that long polymers should approach a limit where their
global motion is controlled by solvent friction alone, with ruggedness of their energy …

Protein aggregation is a challenge to the successful manufacture of protein therapeutics; it
can impose severe limitations on purification yields and compromise formulation stability …

We use a three‐dimensional lattice model of proteins to investigate systematically the global
properties of the polypeptide chains that determine the folding to the native conformation …