Energy Landscapes for the Aggregation of Aβ17–42
K Röder, DJ Wales - Journal of the American Chemical Society, 2018 - ACS Publications
The aggregation of the Aβ peptide (Aβ1–42) to form fibrils is a key feature of Alzheimer's
disease. The mechanism is thought to be a nucleation stage followed by an elongation …
disease. The mechanism is thought to be a nucleation stage followed by an elongation …
Multistep molecular mechanisms of Aβ16-22 fibril formation revealed by lattice Monte Carlo simulations
PH Nguyen, P Derreumaux - The Journal of Chemical Physics, 2023 - pubs.aip.org
As a model of self-assembly from disordered monomers to fibrils, the amyloid-β fragment
Aβ16-22 was subject to past numerous experimental and computational studies. Because …
Aβ16-22 was subject to past numerous experimental and computational studies. Because …
Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide
SIA Cohen, R Cukalevski, TCT Michaels, A Šarić… - Nature …, 2018 - nature.com
Mapping free-energy landscapes has proved to be a powerful tool for studying reaction
mechanisms. Many complex biomolecular assembly processes, however, have remained …
mechanisms. Many complex biomolecular assembly processes, however, have remained …
Early aggregation mechanism of Aβ16− 22 revealed by Markov state models
MU Rahman, K Song, LT Da, HF Chen - International Journal of Biological …, 2022 - Elsevier
Aβ 16–22 is believed to have critical role in early aggregation of full length amyloids that are
associated with the Alzheimer's disease and can aggregate to form amyloid fibrils. However …
associated with the Alzheimer's disease and can aggregate to form amyloid fibrils. However …
Compact fibril-like structure of amyloid β-peptide (1–42) monomers
Amyloid β (Aβ) monomers are the smallest assembly units, and play an important role in
most of the individual processes involved in amyloid fibril formation. An important question is …
most of the individual processes involved in amyloid fibril formation. An important question is …
Energy landscapes of Aβ monomers are sculpted in accordance with Ostwald's rule of stages
D Chakraborty, JE Straub, D Thirumalai - Science Advances, 2023 - science.org
The transition from a disordered to an assembly-competent monomeric state (N*) in
amyloidogenic sequences is a crucial event in the aggregation cascade. Using a well …
amyloidogenic sequences is a crucial event in the aggregation cascade. Using a well …
Pathway complexity of Alzheimer's β-amyloid Aβ16-22 peptide assembly
Recent studies suggest that both soluble oligomers and insoluble fibrils have toxic effects in
cell cultures, raising the interest in determining the first steps of the assembly process. We …
cell cultures, raising the interest in determining the first steps of the assembly process. We …
Pathways of amyloid-β aggregation depend on oligomer shape
One of the main research topics related to Alzheimer's disease is the aggregation of the
amyloid-β peptide, which was shown to follow different pathways for the two major alloforms …
amyloid-β peptide, which was shown to follow different pathways for the two major alloforms …
Structure of ring-shaped Aβ42 oligomers determined by conformational selection
The oligomerization of amyloid beta (Aβ) peptides into soluble non-fibrillar species plays a
critical role in the pathogenesis of Alzheimer's disease. However, it has been challenging to …
critical role in the pathogenesis of Alzheimer's disease. However, it has been challenging to …
Comparing the aggregation free energy landscapes of amyloid beta (1–42) and amyloid beta (1–40)
Using a predictive coarse-grained protein force field, we compute and compare the free
energy landscapes and relative stabilities of amyloid-β protein (1–42) and amyloid-β protein …
energy landscapes and relative stabilities of amyloid-β protein (1–42) and amyloid-β protein …