The native chemical ligation reaction (NCL) involves reacting a C-terminal peptide thioester
with an N-terminal cysteinyl peptide to produce a native peptide bond between the two …

Protecting group chemistry for the cysteine thiol group has enabled a vast array of peptide
and protein chemistry over the last several decades. Increasingly sophisticated strategies for …

Membrane‐associated D‐proteins are an important class of synthetic molecules needed for
D‐peptide drug discovery, but their chemical synthesis using canonical ligation methods …

Natural DNA is exquisitely evolved to store genetic information. The chirally inverted l-DNA,
possessing the same informational capacity but resistant to biodegradation, may serve as a …

Summary E2-ubiquitin (Ub) conjugates are useful chemical biology tools for studying the E3
mechanisms, but so far, the reported systems have involved either no substrates or only …

To synthesize a chirally inverted ribosome with the goal of building mirror-image biology
systems requires the preparation of kilobase-long mirror-image ribosomal RNAs that make …

The chemical synthesis of site‐specifically modified transcription factors (TFs) is a powerful
method to investigate how post‐translational modifications (PTMs) influence TF‐DNA …

D‐peptide ligands can be screened for therapeutic potency and enzymatic stability using
synthetic mirror‐image proteins (D‐proteins), but efficient acquisition of these D‐proteins …

Herpes simplex virus-1 (HSV-1) utilizes multiple viral surface glycoproteins to trigger virus
entry and fusion. Among these glycoproteins, glycoprotein D (gD) functions as a receptor …

The central dogma of modern biology underscores the pivotal roles proteins play in diverse
biological processes, the study of which necessitates advanced methods to produce …