Applications of single-cell sequencing in cancer research: progress and perspectives
Y Lei, R Tang, J Xu, W Wang, B Zhang, J Liu… - Journal of hematology & …, 2021 - Springer
Single-cell sequencing, including genomics, transcriptomics, epigenomics, proteomics and
metabolomics sequencing, is a powerful tool to decipher the cellular and molecular …
metabolomics sequencing, is a powerful tool to decipher the cellular and molecular …
Single-cell and spatial transcriptomics: deciphering brain complexity in health and disease
In the past decade, single-cell technologies have proliferated and improved from their
technically challenging beginnings to become common laboratory methods capable of …
technically challenging beginnings to become common laboratory methods capable of …
Brain cancer stem cells: resilience through adaptive plasticity and hierarchical heterogeneity
Malignant brain tumours are complex ecosystems containing neoplastic and stromal
components that generate adaptive and evolutionarily driven aberrant tissues in the central …
components that generate adaptive and evolutionarily driven aberrant tissues in the central …
Recent advances in droplet microfluidics
Y Ding, PD Howes, AJ deMello - Analytical chemistry, 2019 - ACS Publications
Prominent within this technology set are droplet-based microfluidic systems, 3 in which
passive microfluidic structures are used to rapidly generate and manipulate subnanoliter …
passive microfluidic structures are used to rapidly generate and manipulate subnanoliter …
Hedgehog signaling mechanism and role in cancer
J Jiang - Seminars in cancer biology, 2022 - Elsevier
Cell-cell communication through evolutionarily conserved signaling pathways governs
embryonic development and adult tissue homeostasis. Deregulation of these signaling …
embryonic development and adult tissue homeostasis. Deregulation of these signaling …
[HTML][HTML] METTL3 regulates m6A methylation of PTCH1 and GLI2 in Sonic hedgehog signaling to promote tumor progression in SHH-medulloblastoma
ZW Zhang, X Teng, F Zhao, C Ma, J Zhang, LF Xiao… - Cell Reports, 2022 - cell.com
Summary SHH subgroup medulloblastoma (SHH-MB) is one of the most common malignant
pediatric tumors that arises in the cerebellum. Previously, we showed that RNA m 6 A …
pediatric tumors that arises in the cerebellum. Previously, we showed that RNA m 6 A …
Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevance
Rhabdomyosarcoma (RMS) is a group of pediatric cancers with features of developing
skeletal muscle. The cellular hierarchy and mechanisms leading to developmental arrest …
skeletal muscle. The cellular hierarchy and mechanisms leading to developmental arrest …
Understanding and targeting resistance mechanisms in cancer
Resistance to cancer therapies has been a commonly observed phenomenon in clinical
practice, which is one of the major causes of treatment failure and poor patient survival. The …
practice, which is one of the major causes of treatment failure and poor patient survival. The …
Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis
Medulloblastoma (MB) is the most common malignant childhood brain tumour,, yet the origin
of the most aggressive subgroup-3 form remains elusive, impeding development of effective …
of the most aggressive subgroup-3 form remains elusive, impeding development of effective …
Nuclear condensates of YAP fusion proteins alter transcription to drive ependymoma tumourigenesis
Nuclear localization of HIPPO-YAP fusion proteins has been implicated in supratentorial
ependymoma development. Here, unexpectedly, we find that liquid–liquid phase separation …
ependymoma development. Here, unexpectedly, we find that liquid–liquid phase separation …