Studies on synaptic proteins involved in neurotransmitter release often aim at distinguishing
between their roles in vesicle priming (the docking of synaptic vesicles to the plasma …

Dendritic spines are small protrusions arising from dendrites and constitute the major
compartment of excitatory post-synapses. They change in number, shape, and size …

Understanding how biological neural networks carry out learning using spike-based local
plasticity mechanisms can lead to the development of real-time, energy-efficient, and …

The establishment of a functional cerebral cortex depends on the proper execution of
multiple developmental steps, culminating in dendritic and axonal outgrowth and the …

The postsynaptic density (PSD) of excitatory synapses is built from a wide variety of
scaffolding proteins, receptors, and signaling molecules that collectively orchestrate synaptic …

Dendritic spines are crucial for excitatory synaptic transmission as the size of a spine head
correlates with the strength of its synapse. The distribution of spine head sizes follows a …

The investigation of neurobiological and neuropathological changes that affect synaptic
integrity and function with aging is key to understanding why the aging brain is vulnerable to …

Extracellular potassium [K+] o elevation during synaptic activity retrogradely modifies
presynaptic release and astrocytic uptake of glutamate. Hence, local K+ clearance and …

Our brains continuously acquire and store memories through synaptic plasticity. However,
spontaneous synaptic changes can also occur and pose a challenge for maintaining stable …

High-throughput anatomic data can stimulate and constrain new hypotheses about how
neural circuits change in response to experience. Here, we use fluorescence-based …