Anti-amyloid monoclonal antibodies for the treatment of Alzheimer's disease
J Cummings, AML Osse, D Cammann, J Powell… - BioDrugs, 2024 - Springer
Two monoclonal antibodies (mAbs), aducanumab and lecanemab, have received
accelerated approval from the US FDA for initiation of treatment in early Alzheimer's disease …
accelerated approval from the US FDA for initiation of treatment in early Alzheimer's disease …
Data-driven modelling of neurodegenerative disease progression: thinking outside the black box
Data-driven disease progression models are an emerging set of computational tools that
reconstruct disease timelines for long-term chronic diseases, providing unique insights into …
reconstruct disease timelines for long-term chronic diseases, providing unique insights into …
[HTML][HTML] Alzheimer's disease puzzle: delving into pathogenesis hypotheses
Alzheimer's disease (AD) is a prevalent neurodegenerative disease characterized by both
amnestic and non-amnestic clinical manifestations. It accounts for approximately 60-70% of …
amnestic and non-amnestic clinical manifestations. It accounts for approximately 60-70% of …
[HTML][HTML] Amyloid induced hyperexcitability in default mode network drives medial temporal hyperactivity and early tau accumulation
In early Alzheimer's disease (AD) β-amyloid (Aβ) deposits throughout association cortex and
tau appears in the entorhinal cortex (EC). Why these initially appear in disparate locations is …
tau appears in the entorhinal cortex (EC). Why these initially appear in disparate locations is …
Biomarker-based staging of Alzheimer disease: rationale and clinical applications
J Therriault, SE Schindler, G Salvadó… - Nature Reviews …, 2024 - nature.com
Disease staging, whereby the spatial extent and load of brain pathology are used to
estimate the severity of Alzheimer disease (AD), is pivotal to the gold-standard …
estimate the severity of Alzheimer disease (AD), is pivotal to the gold-standard …
Disease staging of Alzheimer's disease using a CSF-based biomarker model
G Salvadó, K Horie, NR Barthélemy, JW Vogel… - Nature aging, 2024 - nature.com
Biological staging of individuals with Alzheimer's disease (AD) may improve diagnostic and
prognostic workup of dementia in clinical practice and the design of clinical trials. In this …
prognostic workup of dementia in clinical practice and the design of clinical trials. In this …
New precision medicine avenues to the prevention of Alzheimer's disease from insights into the structure and function of γ-secretases
B De Strooper, E Karran - The EMBO Journal, 2024 - embopress.org
Two phase-III clinical trials with anti-amyloid peptide antibodies have met their primary goal,
ie slowing of Alzheimer's disease (AD) progression. However, antibody therapy may not be …
ie slowing of Alzheimer's disease (AD) progression. However, antibody therapy may not be …
Porphyromonas gingivalis and the pathogenesis of Alzheimer's disease
S Liu, CA Butler, S Ayton, EC Reynolds… - Critical Reviews in …, 2024 - Taylor & Francis
The cause of Alzheimer's disease (AD), and the pathophysiological mechanisms involved,
remain major unanswered questions in medical science. Oral bacteria, especially those …
remain major unanswered questions in medical science. Oral bacteria, especially those …
A one-two punch targeting reactive oxygen species and fibril for rescuing Alzheimer's disease
J Wang, P Shangguan, X Chen, Y Zhong, M Lin… - Nature …, 2024 - nature.com
Toxic amyloid-beta (Aβ) plaque and harmful inflammation are two leading symptoms of
Alzheimer's disease (AD). However, precise AD therapy is unrealizable due to the lack of …
Alzheimer's disease (AD). However, precise AD therapy is unrealizable due to the lack of …
Early modulation of the gut microbiome by female sex hormones alters amyloid pathology and microglial function
It is well-established that women are disproportionately affected by Alzheimer's disease. The
mechanisms underlying this sex-specific disparity are not fully understood, but several …
mechanisms underlying this sex-specific disparity are not fully understood, but several …