INTRODUCTION Organisms live by means of the complex, dynamic, three-dimensional (3D)
interplay between millions of components, from the molecular to the multicellular. Visualizing …

Understanding the structure–function relationship of cells and organelles in their natural
context requires multidimensional imaging. As techniques for multimodal 3-D imaging have …

We present a combined report on the results of three editions of the Cell Tracking
Challenge, an ongoing initiative aimed at promoting the development and objective …

How stem cells self-organize to form structured tissues is an unsolved problem. Intestinal
organoids offer a model of self-organization as they generate stem cell zones (SCZs) of …

Information from developmental signaling pathways must be accurately decoded to
generate transcriptional outcomes. In the case of Notch, the intracellular domain (NICD) …

Various challenging constraints must be satisfied in railway alignment design for
topographically complex mountainous regions. The alignment design for such environments …

Confocal microscopy is a powerful tool for the study of cellular receptor trafficking and
endocytosis. Unbiased and robust image analysis workflows are required for the …

A numerical framework is developed for simulating pore-scale liquid water transport in
polymer electrolyte fuel cell (PEFC) diffusion media (DM) as measured by X-ray computed …

Cells sense and integrate external information from diverse sources that include mechanical
cues. Shaping of tissues during development may thus require coordination between …

Abstract Knowledge of what dose-volume histograms can be expected for a previously
unseen patient could increase consistency and quality in radiotherapy treatment planning …