Is composition of brain clot retrieved by mechanical thrombectomy associated with stroke aetiology and clinical outcomes in acute ischemic stroke?—a systematic …

J Huang, MC Killingsworth, SMM Bhaskar - Neurology International, 2022 - mdpi.com
Background: Brain clots retrieved following endovascular thrombectomy in acute ischemic
stroke patients may offer unique opportunities to characterise stroke aetiology and aid stroke …

Advancing Stroke Research on Cerebral Thrombi with Omic Technologies

G Costamagna, S Bonato, S Corti… - International Journal of …, 2023 - mdpi.com
Cerebrovascular diseases represent a leading cause of disability, morbidity, and death
worldwide. In the last decade, the advances in endovascular procedures have not only …

Gene expression profiles of ischemic stroke clots retrieved by mechanical thrombectomy are associated with disease etiology

VM Tutino, S Fricano, A Chien, TR Patel… - Journal of …, 2023 - jnis.bmj.com
Background Determining stroke etiology is crucial for secondary prevention, but intensive
workups fail to classify~ 30% of strokes that are cryptogenic. Objective To examine the …

Profiling of circulating gene expression reveals molecular signatures associated with intracranial aneurysm rupture risk

KE Poppenberg, A Chien, BA Santo, L Chaves… - Molecular diagnosis & …, 2023 - Springer
Background Following detection, rupture risk assessment for intracranial aneurysms (IAs) is
critical. Towards molecular prognostics, we hypothesized that circulating blood RNA …

Swiss vascular biobank: Evaluation of optimal extraction method and admission solution for preserving RNA from human vascular tissue

J Pelisek, Y Yundung, B Reutersberg, L Meuli… - Journal of Clinical …, 2023 - mdpi.com
Proper biobanking is essential for obtaining reliable data, particularly for next-generation
sequencing approaches. Diseased vascular tissues, having extended atherosclerotic …

Plasma-free blood as a potential alternative to whole blood for transcriptomic analysis

Q Chen, X Guo, H Wang, S Sun, H Jiang, P Zhang… - Phenomics, 2023 - Springer
RNA sequencing (RNAseq) technology has become increasingly important in precision
medicine and clinical diagnostics, and emerged as a powerful tool for identifying protein …

New Insights into Cerebral Vessel Disease Landscapes at Single-Cell Resolution: Pathogenetic and Therapeutic Perspectives

M Meneri, S Bonato, D Gagliardi, GP Comi, S Corti - Biomedicines, 2022 - mdpi.com
Cerebrovascular diseases are a leading cause of death and disability globally. The
development of new therapeutic targets for cerebrovascular diseases (eg, ischemic, and …

Multi-omic investigation of retrieved blood clots may identify complex traits associated with ischemic stroke etiology

VM Tutino, BA Santo, KV Snyder… - World …, 2022 - pubmed.ncbi.nlm.nih.gov
Multi-Omic Investigation of Retrieved Blood Clots May Identify Complex Traits Associated with
Ischemic Stroke Etiology Multi-Omic Investigation of Retrieved Blood Clots May Identify Complex …

Transcriptome Analysis Identified SPP1+ Monocytes as a Key in Extracellular Matrix Formation in Thrombi

T Kitano, T Sasaki, T Matsui, M Kohara, K Ogawa… - bioRxiv, 2024 - biorxiv.org
Thrombi follow various natural courses. They are known to become harder over time and
may persist long-term; some of them can also undergo early spontaneous dissolution and …

Plasma-free samples for transcriptomic analysis: a potential alternative to whole blood samples

Q Chen, X Guo, H Wang, S Sun, H Jiang, P Zhang… - bioRxiv, 2023 - biorxiv.org
RNA sequencing (RNAseq) technology has become increasingly important in precision
medicine and clinical diagnostics and emerged as a powerful tool for identifying protein …