Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis
Medulloblastoma (MB) is the most common malignant childhood brain tumour,, yet the origin
of the most aggressive subgroup-3 form remains elusive, impeding development of effective …
of the most aggressive subgroup-3 form remains elusive, impeding development of effective …
Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability
MYC-driven medulloblastomas are highly aggressive childhood brain tumors, however, the
molecular and genetic events triggering MYC amplification and malignant transformation …
molecular and genetic events triggering MYC amplification and malignant transformation …
Gene expression profiling of Group 3 medulloblastomas defines a clinically tractable stratification based on KIRREL2 expression
A Korshunov, K Okonechnikov, D Stichel… - Acta …, 2022 - Springer
Medulloblastomas (MB) molecularly designated as Group 3 (Grp 3) MB represent a more
clinically aggressive tumor variant which, as a group, displays heterogeneous molecular …
clinically aggressive tumor variant which, as a group, displays heterogeneous molecular …
Non-canonical splicing and its implications in brain physiology and cancer
C Pitolli, A Marini, C Sette, V Pagliarini - International Journal of …, 2022 - mdpi.com
The advance of experimental and computational techniques has allowed us to highlight the
existence of numerous different mechanisms of RNA maturation, which have been so far …
existence of numerous different mechanisms of RNA maturation, which have been so far …
Mitochondrial subtype MB-G3 contains potential novel biomarkers and therapeutic targets associated with prognosis of medulloblastoma
Q Li, Y Jia, B Tang, H Yang, Q Yang, X Luo, Y Pan - Biomarkers, 2023 - Taylor & Francis
Background Medulloblastoma is the most common malignant brain tumor in children. There
are four groups, each with different causal mutations, affected pathways and prognosis …
are four groups, each with different causal mutations, affected pathways and prognosis …
Transcriptome analysis stratifies second-generation non-WNT/non-SHH medulloblastoma subgroups into clinically tractable subtypes
A Korshunov, K Okonechnikov, D Schrimpf, S Tonn… - Acta …, 2023 - Springer
Medulloblastoma (MB), one of the most common malignant pediatric brain tumor, is a
heterogenous disease comprised of four distinct molecular groups (WNT, SHH, Group 3 …
heterogenous disease comprised of four distinct molecular groups (WNT, SHH, Group 3 …
[PDF][PDF] WNT-activated, MYC-amplified medulloblastoma displaying intratumoural heterogeneity
S Green, T Hoover, D Doss, K Davidow… - Neuropathol. Appl …, 2023 - researchgate.net
Medulloblastomas (MB) are the most commonly occurring malignant brain tumour in
childhood. The mainstay of therapy incorporates gross total resection followed by …
childhood. The mainstay of therapy incorporates gross total resection followed by …
SMARCA4 loss and mutated β-catenin induce proliferative lesions in the murine embryonic cerebellum
C Göbel, M Schoof, D Holdhof, M Spohn… - Journal of …, 2024 - Soc Neuroscience
Almost all medulloblastomas (MB) of the Wingless/Int-1 (WNT) type are characterized by
hotspot mutations in CTNNB1, and mouse models have convincingly demonstrated the …
hotspot mutations in CTNNB1, and mouse models have convincingly demonstrated the …
PRC2 heterogeneity drives tumor growth in medulloblastoma
Intratumor epigenetic heterogeneity is emerging as a key mechanism underlying tumor
evolution and drug resistance. Epigenetic abnormalities frequently occur in …
evolution and drug resistance. Epigenetic abnormalities frequently occur in …
Identification of an Immunogenic Medulloblastoma-Specific Fusion Involving EPC2 and GULP1
Simple Summary Medulloblastoma is the most common malignant childhood brain tumor
and it is considered poor immunogenic because of its low mutational burden. Nevertheless …
and it is considered poor immunogenic because of its low mutational burden. Nevertheless …