Authors
JD Honeycutt, D Thirumalai
Publication date
1990/5/1
Journal
Proceedings of the National Academy of Sciences
Volume
87
Issue
9
Pages
3526
Publisher
National Acad Sciences
Description
The possibility that several metastable minima exist in which the folded forms of a polypeptide chain have similar structural characteristics but different energies is suggested. The validity of this hypothesis is illustrated with the aid of simulation methods on a model protein that folds into a beta-barrel structure. Some implications of this hypothesis such as the existence of multiple pathways with intermediates for protein folding are discussed.
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Scholar articles
JD Honeycutt, D Thirumalai - Proceedings of the National Academy of Sciences, 1990