Authors
Philip Bradley, Kira MS Misura, David Baker
Publication date
2005/9/16
Journal
Science
Volume
309
Issue
5742
Pages
1868-1871
Publisher
American Association for the Advancement of Science
Description
The prediction of protein structure from amino acid sequence is a grand challenge of computational molecular biology. By using a combination of improved low- and high-resolution conformational sampling methods, improved atomically detailed potential functions that capture the jigsaw puzzle–like packing of protein cores, and high-performance computing, high-resolution structure prediction (<1.5 angstroms) can be achieved for small protein domains (<85 residues). The primary bottleneck to consistent high-resolution prediction appears to be conformational sampling.
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Scholar articles
P Bradley, KMS Misura, D Baker - Science, 2005