Authors
Paula A Rochon, Therese A Stukel, Kathy Sykora, Sudeep Gill, Susan Garfinkel, Geoffrey M Anderson, Sharon-Lise T Normand, Muhammad Mamdani, Philip E Lee, Ping Li, Susan E Bronskill, Connie Marras, Jerry H Gurwitz
Publication date
2005/9/12
Journal
Archives of internal medicine
Volume
165
Issue
16
Pages
1882-1888
Publisher
American Medical Association
Description
Background
Atypical antipsychotic agents are thought to be less likely than older typical agents to produce parkinsonism. This has not been well documented. We compared the risk of development of incident parkinsonism among older adults dispensed atypical relative to typical antipsychotics.
Methods
Retrospective cohort study of all adults 66 years and older in Ontario. We used Cox proportional hazards models to study the association between the type, potency, and dose of antipsychotic dispensed and the development of parkinsonism during 1 year of follow-up.
Results
All 25 769 older adults prescribed antipsychotics were observed for 11 573 person-years, and 449 events of parkinsonism were identified. Relative to individuals dispensed an atypical antipsychotic, those dispensed a typical agent were 30% more likely (adjusted hazard ratio [HR], 1.30; 95% confidence interval [CI], 1.04-1.58) and those exposed …
Total citations
Scholar articles
PA Rochon, TA Stukel, K Sykora, S Gill, S Garfinkel… - Archives of internal medicine, 2005